UBIQUITIN-PROTEASOME

作品数：12被引量：61H指数：4
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相关领域：医药卫生生物学更多>>
相关作者：吴焱秋柴家科苏国栋王海洪杨松成更多>>
相关机构：解放军总医院第一附属医院华中科技大学华南农业大学军事医学科学院更多>>
相关期刊：《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《Journal of Clinical and Translational Hepatology》《Science Bulletin》更多>>
相关基金：国家自然科学基金中国博士后科学基金国家重点基础研究发展计划广东省自然科学基金更多>>
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Demethylzeylasteral induces PD-L1 ubiquitin-proteasome degradation and promotes antitumor immunity via targeting USP22
《Acta Pharmaceutica Sinica B》2024年第10期4312-4328,共17页Yanyan Zhang Yun Huang Dianping Yu Mengting Xu Hongmei Hu Qing Zhang Minchen Cai Xiangxin Geng Hongwei Zhang Jianhua Xia Mengmeng Guo Dong Lu Hanchi Xu Linyang Li Xing Zhang Qun Wang Sanhong Liu Weidong Zhang 
funded by the National Key Research and Development Program of China(2022YFC3502000);National Natural Science Foundation of China(Nos.82141203,82374086,and 82104459);Shanghai Municipal Science and Technology Major Project(ZD2021CY001,China);Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTDD-202004,China);Science and Technology Commission of Shanghai Municipality(20YF1458700,China);Organizational Key Research and Development Program of Shanghai University of Traditional Chinese Medicine(2023YZZ02,China)。
Programmed cell death ligand-1(PD-L1)is a T cell inhibitory immune checkpoint molecule that interacts with programmed cell death-1(PD-1)to promote immune escape of tumor cells.Compared with antibody therapies,small mo...
关键词：DEMETHYLZEYLASTERAL PD-L1 USP22 DEUBIQUITINATION Tumor-infiltrating lymphocytes Colorectal cancer Immune checkpoint blockade Antitumor immunity 
Serum Iron Overload Activates the SMAD Pathway and Hepcidin Expression of Hepatocytes via SMURF1被引量：1
《Journal of Clinical and Translational Hepatology》2024年第3期227-235,共9页Ning Zhang Pengyao Yang Yanmeng Li Qin Ouyang Fei Hou Guixin Zhu Bei Zhang Jian Huang Jidong Jia Anjian Xu 
supported by the National Natural Science Foundation of China(No.82370898);Beijing Natural Science Foundation(No.7202034).
Background and Aims:Liver iron overload can induce hepatic expression of bone morphogenic protein(BMP)6 and activate the BMP/SMAD pathway.However,serum iron overload can also activate SMAD but does not induce BMP6 exp...
关键词：BMP/SMAD pathway HEPCIDIN Holo-transferrin Ubiquitin-proteasome degradation HEMOCHROMATOSIS 
Regulation of chloroplast protein degradation被引量：1
《Journal of Genetics and Genomics》2023年第6期375-384,共10页Yang Sun Jialong Li Lixin Zhang Rongcheng Lin 
supported by grant from the National Key R&D Program of China(2020YFA0907600)。
Chloroplasts are unique organelles that not only provide sites for photosynthesis and many metabolic processes,but also are sensitive to various environmental stresses.Chloroplast proteins are encoded by genes from bo...
关键词：CHLOROPLAST Protein homeostasis PROTEASE UBIQUITIN-PROTEASOME Chlorophagy 
RNF6 promotes myeloma cell proliferation and survival by inducing glucocorticoid receptor polyubiquitination被引量：4
《Acta Pharmacologica Sinica》2020年第3期394-403,共10页Ying Ren Xin Xu Chen-yu Mao Kun-kun Han Yu-jia Xu Bi-yin Cao Zu-bin Zhang Gautam Sethi Xiao-wen Tang Xin-liang Mao 
This work was supported by the National Natural Science Foundation of China(81770154 and 81320108023 to XLM;81873443 to XWT);the Natural Science Foundation of Jiangsu Higher Education Institutes of China(17KJA180010 to XLM,19KJA210002 to XWT);Frontier Clinical Technical Project of the Science and Technology Department of Jiangsu Province(BE2017655 to XWT);The Jiangsu Provinicial Medical Talent(ZDRCA2016045 to XWT);the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).
RNF6,a RING-type ubiquitin ligase,has been identified as an oncogene in various cancers but its role in multiple myeloma(MM)remains elusive.In the present study we first showed that the expression levels of RNF6 in MM...
关键词：multiple MYELOMA RNF6 GLUCOCORTICOID receptor UBIQUITIN-PROTEASOME pathway apoptosis DEXAMETHASONE 
Degradation of proteins by PROTACs and other strategies被引量：32
《Acta Pharmaceutica Sinica B》2020年第2期207-238,共32页Yang Wang Xueyang Jiang Feng Feng Wenyuan Liu Haopeng Sun 
the support from grants(Nos.81573281)of National Natural Science Foundation of China;support from Double First-Class initiative Innovation team project of China Pharmaceutical University(Nos.CPU2018GF11 and CPU2018GY34,China).
Abnormal protein expression or activities are associated with many diseases,especially cancer.Therefore,down-regulating the proteins involved in cancer cell survival proved to be an effective strategy for cancer treat...
关键词：PROTEIN DEGRADATION PROTAC UBIQUITIN-PROTEASOME system E3 UBIQUITIN LIGASE Target PROTEIN Heterobifunctional molecule 
IGF-1 promotes the growth and metastasis of hepatocellular carcinoma via the inhibition of proteasome-mediated cathepsin B degradation被引量：12
《World Journal of Gastroenterology》2015年第35期10137-10149,共13页Tian Lei Xie Ling 
AIM: To investigate the molecular mechanisms of the high IGF-1 level linking diabetes and cancers, which is a risk factor.METHODS: We used cell growth, wound healing and transwell assay to evaluate the proliferation a...
关键词：IGF-1 CATHEPSIN B UBIQUITIN-PROTEASOME system HEPA 
RNF20 promotes the polyubiquitination and proteasome-dependent degradation of AP-2α protein被引量：2
《Acta Biochimica et Biophysica Sinica》2014年第2期136-140,共5页Peng Ren Zhifeng Sheng Yijun Wang Xin Yi Qiuzhi Zhou Jianlin Zhou Shuanglin Xiang Xiang Hu Jian Zhang 
This work was supported by the grants from the National Natural Science Foundation of China （31071150）, China Postdoctoral Science Foundation （2012M511380）, Hunan Postdoctoral Science Foundation （2012RS4016）, and E-Institutes of Shanghai Municipal Education Commission （E03003）.
Transcription factor activator protein 2α （AP-2α is a nega- tive regulator of adipogenesis by repressing the transcription of CCAAT/enhancer binding protein （C/EBPoz） gene. During adipogenesis, AP-2α is degraded...
关键词：AP-2Α RNF20 E3 ubiquitin ligase ubiquitin-proteasome-dependent degradation C/EBPΑ 
Ubiquitin-conjugating enzyme involved in the immune response caused by pathogens invasion被引量：1
《Open Journal of Immunology》2013年第3期93-97,共5页Liang Chen Chen Cheng Chunxia Zhang Qin Yao Ermi Zhao 
Ubiquitin-proteasome pathway (UPP) is a significant way of protein degradation and modification in eukaryotic cell and involved in a complex series of intracellular processes. As a key component in UPP,?ubiquitin-conj...
关键词：Ubiquitin-Conjugating Enzyme UBIQUITIN-PROTEASOME Pathway PATHOGEN Immune Response 
Upregulation of SIRT1 by 17β-estradiol depends on ubiquitin-proteasome degradation of PPAR-γ mediated by NEDD4-1被引量：4
《Protein & Cell》2013年第4期310-321,共12页Limin Han Pan Wang Ganye Zhao Hui Wang Meng Wang Jun Chen Tanjun Tong 
supported by grants from the National Basic Research Programs of China(Nos.2012CB911203 and 2013CB530801);the National Natural Science Foundation of China(Grant No.31100997);a China Postdoctoral Science Foundation funded project(No.20100470169).
17β-estradiol (E2) treatment of cells results in an upregulation of SIRT1 and a down-regulation of PPARγ. The decrease in PPARγ expression is mediated by increased degradation of PPARγ. Here we report that PPARγ ...
关键词：17Β-ESTRADIOL PPARγ senescence SIRT1 UBIQUITINATION 
新书推介——泛素蛋白酶水解系统（The Ubiquitin-Proteasome Proteolytic System）
《中国动脉硬化杂志》2005年第3期362-362,共1页胡必利（编译） 
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