多发性硬化与调节性T细胞相关研究进展  

Research progress of multiple sclerosis and regulatory T cells

作　　者：王博[1] 孙博[1] Wang Bo;Sun Bo(Department of Neurobiology,Harbin Medical University,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学神经生物教研室,哈尔滨150081

出　　处：《国际免疫学杂志》2022年第5期493-497,共5页International Journal of Immunology

基　　金：国家自然科学基金(81430035,81771305,81870955)。

摘　　要：多发性硬化(multiple sclerosis,MS)是一种自身免疫性中枢神经系统疾病,是由自身免疫耐受性缺失所致。尽管自身免疫耐受受损的机制尚未完全阐明,但相关研究表明,调节性T细胞(regulatory T cells,Treg)与MS发病机制密切相关。Treg细胞可以通过抑制体内效应T细胞亚群的增殖与活化并维持自身免疫耐受从而抑制炎症及自身免疫反应。Treg细胞功能的恢复与增强对改善MS疾病有潜在价值,文章就Treg细胞在MS中作用的研究进展进行综述。Multiple sclerosis(MS)is an autoimmune central nervous system disease,which is caused by loss of autoimmune tolerance.Although the mechanism of impaired self-tolerance has not been fully elucidated,related studies have shown that regulatory T cells(Treg)are closely related to the pathogenesis of MS.Treg cells can inhibit inflammation and autoimmune response by inhibiting the proliferation and activation of effector T cell subsets in vivo and maintaining autoimmune tolerance.The restoration and enhancement of Treg cell function has potential value in improving MS disease.Therefore,the current research progress of regulatory T cells in MS is reviewed.

关 键 词：多发性硬化 调节性T细胞 发病机制 

分 类 号：R744.51[医药卫生—神经病学与精神病学]