Developmental origins of adult diseases  

作　　者：Jiaying Mo Xuanqi Liu Yutong Huang Renke He Yu Zhang Hefeng Huang 

机构地区：[1]Department of Obstetrics and Gynecology,The Fourth Affiliated Hospital,International Institutes of Medicine,Zhejiang University School of Medicine,Yiwu,Zhejiang Province,China [2]The Key Laboratory of Reproductive Genetics(Zhejiang University),Ministry of Education,Zhejiang University School of Medicine,Hangzhou,Zhejiang Province,China

出　　处：《Medical Review》2022年第5期450-470,共21页医学评论（英文）

基　　金：supported by the National Natural Science Foundation of China(82088102);CAMS Innovation Fund for Medical Sciences(2019-I2M-5-064);Collaborative Innovation Program of Shanghai Municipal Health Commission(2020CXJQ01);Clinical Research Plan of SHDC(SHDC2020CR1008A),Shanghai Frontiers Science Research Base of Reproduction and Development.

摘　　要：The occurrence and mechanisms of developmental adult diseases have gradually attracted attention in recent years.Exposure of gametes and embryos to adverse environments,especially during plastic development,can alter the expression of certain tissue-specific genes,leading to increased susceptibility to certain diseases in adulthood,such as diabetes,cardiovascular disease,neuropsychiatric,and reproductive system diseases,etc.The occurrence of chronic disease in adulthood is partly due to genetic factors,and the remaining risk is partly due to environmental-dependent epigenetic information alteration,including DNA methylation,histone modifications,and noncoding RNAs.Changes in this epigenetic information potentially damage our health,which has also been supported by numerous epidemiological and animal studies in recent years.Environmental factors functionally affect embryo development through epimutation,transmitting diseases to offspring and even later generations.This review mainly elaborated on the concept of developmental origins of adult diseases,and revealed the epigenetic mechanisms underlying these events,discussed the theoretical basis for the prevention and treatment of related diseases.

关 键 词：embryos development EPIGENETIC GAMETES non-communicable diseases. 

分 类 号：R59[医药卫生—内科学]