癫痫发作后全面性脑电抑制作为癫痫猝死脑电图标志物研究进展  

Research progress of generalized electroencephalography suppression after epileptic seizure as an electroencephalography marker of sudden unexpected death in epilepsy

作　　者：陈梅 王后芬 史梦婷 于云莉 CHEN Mei;WANG Hou-fen;SHI Meng-ting;YU Yun-li(Clinical School of Medicine,Guizhou Medical University,Guiyang 550004,Guizhou,China;Department of Neurology,The Affiliated Hospital of Guizhou Medical University,Guiyang 550004,Guizhou,China)

机构地区：[1]贵州医科大学临床医学院,贵阳550004 [2]贵州医科大学附属医院神经内科,贵阳550004

出　　处：《中国现代神经疾病杂志》2022年第11期1000-1004,共5页Chinese Journal of Contemporary Neurology and Neurosurgery

基　　金：贵州省卫生健康委科学技术基金资助项目(项目编号:gzwkj2021-29);贵州医科大学附属医院博士科研启动基金资助项目(项目编号:gyfybsky-2021-32)。

摘　　要：目前尚缺乏可靠的癫痫猝死(SUDEP)预测指标,给癫痫患者的生命安全造成巨大威胁。随着研究深入,癫痫发作特别是全面性强直-阵挛发作后,脑电图可监测到癫痫发作后全面性脑电抑制(PGES),自此PGES作为SUDEP可能的脑电图标志物备受关注。本文拟对PGES病理生理学机制、相关因素及最新研究进展进行综述,分析PGES的产生及其与SUDEP的关联性。At present,there is a lack of reliable prediction index for sudden unexpected death in epilepsy(SUDEP),which poses a great threat to the lives of patients with epilepsy.With the deepening of research,it has been found that postictal generalized electroencephalography suppression(PGES)occurs in EEG monitoring after seizure,especially generalized tonic-clonic seizure(GTCS).Since then,PGES has attracted much attention as a possible EEG marker of SUDEP.Combined with the study of the pathophysiological mechanism,related factors of PGES phenomenon,and this paper further analyzes the relationship between the occurrence of PGES and SUDEP.

关 键 词：癫痫 猝死 脑电抑制(非MeSH词) 脑电描记术 综述 

分 类 号：R742.1[医药卫生—神经病学与精神病学]