不同中国肝癌分期患者肝癌根治性切除术后的临床疗效差异与预后影响因素  

Differences of Clinical Efficacy and Prognostic Factors of Patients with Different Chinese HCC Stages

作　　者：张蓉 张婕 潘亚杰[1] ZHANG Rong;ZHANG Jie;PAN Yajie(The First Affiliated Hospital of Zhengzhou University,Zhengzhou,450000)

机构地区：[1]郑州大学第一附属医院,450000

出　　处：《实用癌症杂志》2023年第2期240-242,共3页The Practical Journal of Cancer

摘　　要：目的分析不同中国肝癌分期(CNLC)患者肝癌根治性切除术后的临床疗效差异与预后影响因素。方法回顾性选取125例肝细胞癌(HCC)患者,收集患者一般信息、实验室检测指标[谷丙转氨酶(ALT)、谷草转氨酶(AST)、甲胎蛋白(AFP)]及病理学检查结果。术后进行3年随访,并依据随访生存与否分为生存组、死亡组。统计患者3年总生存率(OS),比较不同CNLC分期HCC患者3年OS,采用多因素Logistic回归方法对预后影响因素进行分析。结果125例HCC患者3年OS为67.20%(84/125),其中CNLCⅠa期患者的3年OS高于Ⅰb期、Ⅱa期、Ⅱb期、Ⅲa期、Ⅲb期患者,Ⅰb期患者3年OS高于Ⅲa期、Ⅲb期患者,有统计学差异(P<0.05)。死亡组肿瘤数目多发、肿瘤破裂、低分化及血管侵犯患者占比高于生存组,死亡组ALT、AST、AFP水平高于生存组,有统计学差异(P<0.05);Logistic回归分析显示,肿瘤多发、肿瘤破裂、低分化、血管侵犯、ALT、AST、AFP为影响患者预后的独立危险因素(P<0.05且OR≥1)。结论不同CNLC分期HCC患者术后OS差异较大,肿瘤数目为多发、肿瘤破裂、低分化、血管侵犯、ALT、AST、AFP为影响患者预后的独立危险因素。Objective To analyze the difference of clinical efficacy and prognosis factors after curative resection in different Chinese liver cancer stage(CNLC)patients.Methods 125 patients with hepatocellular carcinoma(HCC)were selected retrospectively to collect patient general information,laboratory test indexes[glutamate transaminase(ALT),glutamate transaminase(AST),alpha-fetoprotein(AFP)]and pathological examination results.The follow-up was followed for 3 years and divided into survival and death groups according to follow-up survival.The 3-year overall survival rate(OS)was counted,the 3-year OS of HCC patients with different CNLC stages was compared,and the multivariate Logistic regression method was used to analyze the prognostic factors.Results Of the 125 HCC patients,3-year OS was 67.20%(84/125),3-year OS of stage CNLCⅠa patients was higher than stageⅠb,Ⅱa,Ⅱb,Ⅲa,Ⅲb,and 3-year OS of stage Ib patients was higher than stageⅢa andⅢb,respectively(P<0.05).The number of tumors,tumor rupture,low differentiation and vascular invasion was higher than survival,and ALT,AST and AFP were higher(P<0.05);Logistic regression analysis,tumor rupture,low differentiation,vascular invasion,ALT,AST and AFP were independent risk factors(P<0.05 and OR≥1).Conclusion The postoperative OS of different CNLC stages of HCC patients varied greatly,and the number of tumors was multiple,tumor rupture,low differentiation,vascular invasion,ALT,AST,and AFP were independent risk factors affecting patient prognosis.

关 键 词：肝细胞癌 中国肝癌分期 肝癌根治性切除术 临床疗效 预后 

分 类 号：R735.7[医药卫生—肿瘤]