乳腺癌早期骨转移的危险因素分析  

Analysis of Risk Factors for Early Bone Metastases in Breast Cancer

作　　者：王静[1] 周毅娟[1] 张慧[1] WANG Jing;ZHOU Yijuan;ZHANG Hui(Henan Cancer Hospital,Zhengzhou,450000)

机构地区：[1]河南省肿瘤医院,450000

出　　处：《实用癌症杂志》2023年第2期296-298,共3页The Practical Journal of Cancer

摘　　要：目的探讨乳腺癌早期骨转移的危险因素。方法选取乳腺癌患者196例,所有患者均进行乳腺癌根治术治疗,术后随访18个月,统计骨转移发生情况,根据骨转移情况将患者分为骨转移组与未转移组,统计2组临床资料,包括年龄、月经状态、病理类型、临床分期、是否合并基础疾病、病灶直径、手术方式、腋窝淋巴结清扫数目,分析乳腺癌早期骨转移的危险因素。结果随访18个月,196例乳腺癌患者中,有28例发生骨转移,发生率为14.29%(28/196)。骨转移组年龄>60岁、临床分期为Ⅲ期、病灶直径>5 cm、腋窝淋巴结清扫数目>10个的患者占比均高于未转移组,差异有统计学意义(P<0.05);2组月经状态、病理类型、是否合并基础疾病、手术方式等对比,差异无统计学意义(P>0.05);Logistic回归分析:年龄>60岁、临床分期为Ⅲ期、病灶直径>5 cm、腋窝淋巴结清扫数目>10个是乳腺癌早期骨转移的独立危险因素(P<0.05且OR≥1)。结论乳腺癌根治术后早期骨转移发生率较高,年龄>60岁、临床分期为Ⅲ期、病灶直径>5 cm、腋窝淋巴结清扫数目>10个是其独立危险因素,临床需予以高度重视。Objective To investigate the risk factors for early bone metastasis in breast cancer.Methods Clinical data of 196 breast cancer patients were retrospectively analyzed.All patients underwent radical breast cancer adenocarcinoma and were follow-up for 18 months to count the occurrence of bone metastasis in the 2 groups.Patients were divided into bone metastatic and unmetastatic groups,including clinical data,including age,menstrual status,pathological type,clinical stage,combined underlying disease,lesion diameter,surgical method,and number of axillary lymph node dissection.Analysis of the risk factors for early bone metastasis in breast cancer.Results Follow-up for 18 months,Of the 196 breast cancer patients,28 cases developed bone metastases,The incidence rate was 14.29%(28/196);The bone metastatic group,>60 years,clinical stage,and the number of axillary lymph node dissection were higher than in the unmetastatic group,Differences were statistically significant(P<0.05);Comparison of menstrual status,pathological type,whether combined with basic diseases,surgical methods and so on,No difference was statistically significant(P>0.05);Logistic regression analysis showed that Age>60,clinical stage,>5 cm,axillary lymph node dissection>10 were independent risk factors for early bone metastasis in breast cancer(P<0.05 and OR≥1).Conclusion The high incidence of bone metastasis in breast cancer,with>60 years,clinical stage,focal diameter>5 cm,axillary node dissection are independent risk factors and should be paid great attention to in clinical practice.

关 键 词：乳腺癌 早期骨转移 危险因素 

分 类 号：R737.9[医药卫生—肿瘤]