BCAP31在结直肠癌组织中的表达及其临床意义  

The expression and clinical significance of BCAP31 in colorectal cancer tissues

作　　者：王琦 雷雯淇 程琳 韩彬[3] 李志贵 汪晓东[4] 周春阳[1] 周黎明 WANG Qi;LEI Wenqi;CHENG Lin;HAN Bin;LI Zhigui;WANG Xiaodong;ZHOU Chunyang;ZHOU Liming(School of Pharmacy,North Sichuan Medical College,Sichuan Nanchong 637000,China;Department of Pharmacology,West China School of Basic Medical Sciences and Forensic Medicine,Sichuan University,Sichuan Chengdu 610041,China;Pharmacy Department of Affiliated Hospital of North Sichuan Medical College,Sichuan Nanchong 637000,China;Department of Gastrointestinal Surgery,West China Hospital,Sichuan University,Sichuan Chengdu 610041,China)

机构地区：[1]川北医学院药学院,四川南充637000 [2]四川大学华西基础医学与法医学院药理教研室,四川成都610041 [3]川北医学院附属医院药剂科,四川南充637000 [4]四川大学华西医院胃肠外科,四川成都610041

出　　处：《现代肿瘤医学》2023年第4期693-697,共5页Journal of Modern Oncology

摘　　要：目的:研究结直肠癌组织中BCAP31的表达情况及其与临床病理特征的关系。方法:利用GEPIA数据库和HPA数据库分析BCAP31在结直肠癌中的表达情况,UALCAN数据库分析BCAP31在结直肠癌中的表达及与结直肠癌临床病理特征的关系,在临床样本中用实时荧光定量PCR法(real-time fluorescence quan⁃titative polymerase chain reaction,RT-qPCR)和免疫印迹法(western blot,WB)检测BCAP31在结直肠癌和癌旁组织中mRNA和蛋白的表达情况,卡方检验分析BCAP31 mRNA表达与临床病理特征的相关性。结果:与癌旁组织相比,BCAP31在结直肠癌中高表达(P<0.05),临床相关性分析其表达与淋巴结转移(P<0.05)和TNM分期有关(P<0.05),而与患者的年龄、性别、肿瘤部位、肿瘤分级、T分期和M分期无明显相关性(P>0.05)。结论:BCAP31在结直肠癌中高表达,且与肿瘤的淋巴结转移和TNM分期有关。BCAP31可作为结直肠癌治疗诊断的分子标志物。Objective:To study the expression of BCAP31 in human colorectal carcinomas and pericarcinous tis⁃sues,and analyze its correlation with clinical pathological parameters.Methods:GEPIA and HPA database were used to analyze the expression of BCAP31 in colorectal cancer,and UALCAN database was used to analyze the expression of BCAP31 in colorectal cancer and its relationship with clinicopathological features of colorectal cancer.RT-qPCR and WB were used to detect the mRNA and protein expression of BCAP31 in colorectal cancer and pericarcinous tis⁃sues.Results:Compared with pericarcinous tissues,BCAP31 was highly expressed in colorectal cancer(P<0.05),and its expression was correlated with lymph node metastasis(P<0.05)and TNM stage(P<0.05),but not with age,gender,tumor site,tumor grade,T stage and M stage(P>0.05).Conclusion:BCAP31 is highly expressed in colorectal cancer and is associated with lymph node metastasis and TNM stage.BCAP31 can be used as a molecular marker for the treatment and diagnosis of colorectal cancer.

关 键 词：B细胞受体相关蛋白31 结直肠癌 生物信息学分析 

分 类 号：R735.3[医药卫生—肿瘤]