非编码RNA靶向脂代谢重编程参与肝细胞癌恶性生物学表型  

Non-coding RNAs as remodelers of lipid metabolic reprogramming of malignant biolog⁃ical phenotype in hepatocellular carcinoma

作　　者：程健泽 王玉敏 CHENG Jianze;WANG Yumin(Department of General Surgery,the Affiliated Hospital of Chifeng University,Inner Mongolia Chifeng 024000,China;Department of Re-spiratory and Critical Care Medicine,Aerospace Center Hospital,Peking University Aerospace School of Clinical Medicine,Beijing 100049,China)

机构地区：[1]赤峰学院附属医院普外科,内蒙古赤峰024000 [2]航天中心医院/北京大学航天临床医学院呼吸与危重症医学科,北京100049

出　　处：《现代肿瘤医学》2023年第4期759-763,共5页Journal of Modern Oncology

基　　金：北京市海淀区卫生健康发展科研培育计划(编号:HP2021-19-50701);航天中心医院院级课题(编号:YN202104);中国航天科工集团课题(编号:2020-LCYL-009)。

摘　　要：代谢重编程是肿瘤细胞的主要特征之一。脂质代谢重编程参与肝细胞癌(hepatocellular carci⁃noma,HCC)发病机制。非编码RNA(non-coding RNAs,ncRNAs)是具有有限的或没有编码蛋白质能力的一类功能性RNA。多种ncRNAs调控脂质代谢。本文首先总结了肝癌发生和发展过程中细胞内主要脂肪酸代谢途径的改变情况,进一步总结了ncRNA调控脂代谢异常参与HCC恶性生物学表型的研究进展。本文介绍临床ncRNAs通过调控脂质代谢影响HCC表型的进展,为临床靶向性肿瘤治疗提供新的策略。Metabolic reprogramming is considered to be one of the top characteristics of tumor cells.Recent studies have uncovered the importance of lipid metabolic reprogramming in hepatocellular carcinoma(HCC).Non-coding RNAs(ncRNAs)are functional RNAs with limited or no protein-coding ability.Ample evidence has shown that di⁃vergent groups of ncRNAs play an important role in lipid metabolism.In this review,we first summarize the main al⁃tered intracellular fatty acid processes to support cancer initiation and progression in HCC.Next,we describe the most important regulatory ncRNAs may target the lipid metabolic reprogramming in HCC.The current review briefly intro⁃duces the regulatory effect of ncRNAs on lipid metabolism in HCC,hoping to provide new strategies for clinical targe⁃ting tumor therapy.

关 键 词：非编码RNA 脂代谢重编程 肝细胞癌 恶性生物学表型 

分 类 号：R735.7[医药卫生—肿瘤]