孤独症谱系障碍儿童健康同胞的社会交往能力  

Social interaction ability in healthy siblings of children with autism spectrum disorder

作　　者：赵荔阳 尹婷妮 吉兆正 汤欣舟 宫小云 刘勤一 苏醒 韩刚强 王慧[1] 李雪[1] 刘靖[1] ZHAO Liyang;YIN Tingni;JI Zhaozheng;TANG Xinzhou;GONG Xiaoyun;LIU Qinyi;SU Xing;HAN Gangqiang;WANG Hui;LI Xue;LIU Jing(Peking University Sixth Hospital,Peking University Institute of Mental Health,NHC Key Laboratory of Mental Health(Peking University),National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital),Beijing 100083,Chin)

机构地区：[1]北京大学第六医院,北京大学精神卫生研究所,国家卫生健康委员会精神卫生学重点实验室(北京大学),国家精神心理疾病临床医学研究中心(北京大学第六医院),北京10008

出　　处：《中国心理卫生杂志》2023年第3期192-198,共7页Chinese Mental Health Journal

基　　金：国家重点研发计划资助(2017YFC1309900);国家自然科学基金(81571339);北京市卫生健康委员会资助(BHTPP202060)。

摘　　要：目的:探讨孤独症谱系障碍(ASD)儿童的健康同胞(ASD-Sibs)的社会交往能力特点,并探索ASD-Sibs是否存在更广泛的孤独症表型。方法:采用横断面研究方法,入组年龄组间匹配的5.5~18岁的符合美国精神障碍诊断与统计手册第5版(DSM-5)ASD诊断标准的儿童51例,ASD-Sibs51例,以及非ASD-Sibs的正常儿童(TD)53例,采用社交反应量表(SRS)对所有被试的社会交往能力进行评定。结果:ASD-Sibs组和TD组SRS总分及社交知觉、认知、沟通、动机和孤独症行为方式5个因子分均低于ASD组(均P<0.001);ASD-Sibs组SRS总分、社交知觉及社交认知因子分均低于TD组(均P<0.05),两组间社交沟通、社交动机和孤独症行为方式因子分差异均无统计学意义(均P>0.05)。男性被试中,ASD-Sibs组与TD组SRS总分及各因子分差异均无统计学意义(均P>0.05),并均低于ASD组(均P<0.001)。结论:本研究显示孤独症谱系障碍儿童健康同胞的社会交往能力无异常,不支持其存在社会交往能力损害的更广泛孤独症表型的假说。Objective:To explore the characteristics of social interaction ability of healthy siblings of children with autism spectrum disorder(ASD-Sibs),and to explore whether ASD-Sibs have a broader autism phenotype(BAP).Methods:This study adopted cross-sectional approach.Fifty-one children meeting criteria of ASD of the Diagnostic and Statistical Manual of Mental Disorder,Fifth Edition(DSM-5),51 healthy ASD-Sibs and 53 typical developmental(TD)children who were not siblings of ASD were recruited in the study,all aged5.5 to 18.0 years old and matched among the three groups.The Social Responsiveness Scale(SRS)was used to evaluate the social interaction ability of all the subjects.Results:The total scores of SRS and scores of five factors including social awareness,social cognition,social communication,social motivation and auti stic mannerisms were lower in the ASD-Sibs group and TD group than in the ASD group(Ps<0.001).And the total scores of SRS and scores of so-cial awareness and social cognition were lower in the ASD-Sibs group than in the TD group(Ps<0.05),but there was no significant difference in social communication,social motivation and autistic mannerisms between the two groups(Ps>0.05).Among the male subjects,there was no significant difference in the total scores of SRS and the scores of all factors between the ASD-Sibs group and the TD group(Ps>0.05),but they were significantly lower than those in the ASD group(Ps<0.001).Conclusion:Healthy siblings of children with autism spectrum disorder have no atypical social interaction ability,which does not support the hypothesis that they have a broader autism phenotype in social interaction impairment.

关 键 词：孤独症谱系障碍 孤独症谱系障碍儿童同胞 社会交往能力 

分 类 号：R749.94[医药卫生—神经病学与精神病学]