帕金森病患者的生态执行功能初步研究  

Preliminary study on ecological executive function in patients with Parkinson′sdisease

作　　者：莫宇佳 王荣丽[1] 王宁华[1,2] MO Yujia;WANG Rongli;WANG Ninghua(Department of Rehabiliation Medicine,Peking University First Hospital,Bejng 100034,China;Institute of Medical Technolo-gy,Peking University Health Science Center,Beijing 100191,China)

机构地区：[1]北京大学第一医院康复医学科,北京100034 [2]北京大学医学部医学技术研究院,北京100191

出　　处：《中国心理卫生杂志》2023年第3期240-247,共8页Chinese Mental Health Journal

基　　金：国家重点研发计划政府间国际科技创新合作重点专项——中美合作项目“面向脊髓损伤运动康复的动态脊柱支撑机器人关键技术研究及临床应用”(2018YFE0114700);国家重点研发计划“主动健康和老龄化科技应对”专项“日常生活及认知康复辅具的智能适配及示范应用”(2020YFC2005700)。

摘　　要：目的:探究帕金森病(PD)患者的生态执行功能特征。方法:招募33例符合《中国帕金森病的诊断标准(2016版)》的PD患者及35名认知功能正常中老年人,采用中文版10项周历活动规划(WCPA-10)评估生态执行功能,分析PD组与认知正常组WCPA-10指标结果的差异以及PD组WCPA-10指标间的相关性。结果:PD组WCPA-10的效率、准确填入的安排数、规则遵守、错误类型、时间意识和准确性估计得分低于对照组(均P<0.05),PD组总时间与计划时间2呈高度正相关(r=0.72,P<0.01),填入的安排数与准确填入的安排数、效率与总时间、计划时间1与计划时间2、计划时间1与总时间、策略使用数与准确填入的安排数之间呈中度正相关(r>0.52,均P<0.01)。结论:PD患者较认知功能正常的中老年人存在生态执行功能减退,受累的认知成分包括抑制控制、工作记忆及自我意识。Objectives:To investigate the characteristics of ecological executive function in patients with Parkinson′s disease(PD).Methods:Thirty-three patients who were diagnosed as PD according to the Diagnostic Criteria of Parkinson′s Disease in China(2016) and 35 elder individuals without cognitive impairment were recruited.The Chinese version of 10-Item Weekly Calendar Planning Activity(WCPA-10) was conducted to evaluate ecological executive function.Between-group variance and correlation between indices of WCPA-10 in PD group was analyzed.Results:In WCPA-10,the performance on efficiency, accurate entered appointment, followed rules, error type, time awareness, accuracy estimation were significantly worse in PD group than in normal cognition group(P<0.05).Total time and planning time 2 were highly correlated(r=0.72,P<0.01),moderate correlation was found between entered appointment and accurate entered appointment, efficiency and total time, planning time 1 and 2,planning time 1 and total time, strategy use and accurate entered appointment(r>0.52,Ps<0.01).Conclusion:Patients with Parkinson′s disease may have significant deficits in ecological executive function compared with elder adults without cognitive impairment.The involved cognitive components are inhibitory control, working memory, and self-awareness.

关 键 词：帕金森病 生态执行功能 中文版周历活动规划 

分 类 号：R749.16[医药卫生—神经病学与精神病学]