Radioimmunotherapy-induced intratumoral changes in cervical squamous cell carcinoma at single-cell resolution  

作　　者：Chao Liu Hao Yu Rui Huang Tianyu Lei Xiaohui Li Ming Liu Qingyu Huang Qilian Du Ligang Xing Jinming Yu 

机构地区：[1]Department of Radiation Oncology and Shandong Provincial Key Laboratory of Radiation Oncology,Shandong Cancer Hospital and Institute,Shandong First Medical University and Shandong Academy of Medical Sciences,Jinan,Shandong 250117,P.R.China [2]Research Unit of Radiation Oncology,Chinese Academy of Medical Sciences,Jinan,Shandong 250117,P.R.China [3]Department of Gynecologic Oncology,Shandong Cancer Hospital and Institute,Shandong First Medical University and Shandong Academy of Medical Sciences,Jinan,Shandong 250117,P.R.China [4]Department of Oncology,Renmin Hospital ofWuhan University,Wuhan,Hubei 430060,P.R.China

出　　处：《Cancer Communications》2022年第12期1407-1411,共5页癌症通讯（英文）

基　　金：supported by funds fromtheNationalNatural Science Foundation of China(82030082);the Academic Promotion Program of Shandong First Medical University(2019ZL002);the Radiation Oncology Innovate Unit,Chinese Academy of Medical Sciences(2019RU071);Key Research and Development Project of Shandong Province of China(2021CXGC011102);Shandong Provincial Natural Science Foundation(ZR2021QH006);Beijing Bethune Charitable Foundation(flzh202118).

摘　　要：Dear Editor,Increasing numbers of studies have revealed the immunomodulating effects of radiotherapy when combined with immune checkpoint inhibitors,as radioimmunotherapy has proven to be a promising treatment[1].Radioimmunotherapy has shown significantly improved tumor responses than radiotherapy or immunotherapy alone in various malignant tumors[2–4].It has also been applied to cervical cancer in multiple ongoing clinical trials(NCT03612791[5]and NCT02635360[6]).However,tumor recurrence andmetastasis are often unavoidable.As such,investigations into radioimmunotherapy-induced tumor ecosystem evolution are essential for guiding improvements in treatment strategies that achieve better long-term disease control.To date,several studies have investigated radiochemotherapy-induced tumor ecosystem evolution using bulk RNA-sequencing and immune staining[7,8].However,these findings were limited owing to the cellular heterogeneity in cancers.Single-cell RNA-sequencing(scRNA-seq)enables the characterization of cell compositions and transcriptomic states in the tumor at single-cell resolution.

关 键 词：CERVICAL CHEMOTHERAPY treatment 

分 类 号：R737.33[医药卫生—肿瘤]