Seronegative Autoimmune Hepatitis  

作　　者：Sriya A.Bhumi George Y.Wu 

机构地区：[1]Department of Medicine,University of Connecticut Health Center,Farmington,CT,USA [2]Department of Medicine,Division of Gastroenterology-Hepatology,University of Connecticut Health Center,Farmington,CT,USA

出　　处：《Journal of Clinical and Translational Hepatology》2023年第2期459-465,F0003,共8页临床与转化肝病杂志（英文版）

摘　　要：Autoimmune hepatitis(AIH)is a relatively rare liver disease with varying worldwide incidence of from 0.7 to 2 per 100,000 people.It is characterized by the presence of auto-antibodies.However,an average of 10% of AIH cases have AIH symptoms and pathology but lack autoimmune serology.For such seronegative AIH(snAIH)cases,there is currently no established diagnostic algorithm for diagnosis.and improper or delayed diagnosis of snAIH can lead to no or inappropriate treatment that results in progression to fulminant hepatitis or cirrhosis.This review aims to review the current literature and to present an update of seronegative autoimmune hepatitis,including its pathophysiology,clinical presentation,methods of diagnosis,and treatment in order to increase awareness and emphasize the necessity for timely management.

关 键 词：Seronegative autoimmune hepatitis Autoantibody negative Autoimmune hepatitis Cryptogenic hepatitis 

分 类 号：R575.1[医药卫生—消化系统]