Epigenetic regulation of aging:implications for interventions of aging and diseases  

作　　者：Kang Wang Huicong Liu Qinchao Hu Lingna Wang Jiaqing Liu Zikai Zheng Weiqi Zhang Jie Ren Fangfang Zhu Guang-Hui Liu 

机构地区：[1]State Key Laboratory of Membrane Biology,Institute of Zoology,Chinese Academy of Sciences,100101 Beijing,China [2]State Key Laboratory of Stem Cell and Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences,100101 Beijing,China [3]University of Chinese Academy of Sciences,100049 Beijing,China [4]School of Biomedical Engineering,Shanghai Jiao Tong University,200030 Shanghai,China [5]CAS Key Laboratory of Genomic and Precision Medicine,Beijing Institute of Genomics,Chinese Academy of Sciences and China National Center for Bioinformation,100101 Beijing,China [6]Hospital of Stomatology,Sun Yat-sen University,510060 Guangzhou,China [7]Guangdong Provincial Key Laboratory of Stomatology,Guanghua School of Stomatology,Sun Yat-sen University,510060 Guangzhou,China [8]Institute for Stem Cell and Regeneration,Chinese Academy of Sciences,100101 Beijing,China [9]Advanced Innovation Center for Human Brain Protection,National Clinical Research Center for Geriatric Disorders,Xuanwu Hospital,Capital Medical University,100053 Beijing,China [10]Beijing Institute for Stem Cell and Regenerative Medicine,100101 Beijing,China

出　　处：《Signal Transduction and Targeted Therapy》2022年第12期4283-4304,共22页信号转导与靶向治疗（英文）

基　　金：National Key Research and Development Program of China(2020YFA0804000);Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16010000);CAS Project for Young Scientists in Basic Research(YSBR-076,YSBR-012);National Natural Science Foundation of China(81921006,92149301,92168201,92049116,32121001,82100140,31970597);National Key Research and Development Program of China(2020YFA08034012019YFA0802202);Program of the Beijing Natural Science Foundation(Z190019);Tencent Foundation(2021–1045),K.C.Wong Education Foundation(GJTD-2019-08),Youth Innovation Promotion Association of CAS(E1CAZW0401);Science&Technology Innovation 2030 of The Ministry of Science and Technology of China(2022ZD0214200).

摘　　要：Aging is accompanied by the decline of organismal functions and a series of prominent hallmarks,including genetic and epigenetic alterations.These aging-associated epigenetic changes include DNA methylation,histone modification,chromatin remodeling,non-coding RNA(ncRNA)regulation,and RNA modification,all of which participate in the regulation of the aging process,and hence contribute to aging-related diseases.Therefore,understanding the epigenetic mechanisms in aging will provide new avenues to develop strategies to delay aging.Indeed,aging interventions based on manipulating epigenetic mechanisms have led to the alleviation of aging or the extension of the lifespan in animal models.Small molecule-based therapies and reprogramming strategies that enable epigenetic rejuvenation have been developed for ameliorating or reversing aging-related conditions.In addition,adopting health-promoting activities,such as caloric restriction,exercise,and calibrating circadian rhythm,has been demonstrated to delay aging.Furthermore,various clinical trials for aging intervention are ongoing,providing more evidence of the safety and efficacy of these therapies.Here,we review recent work on the epigenetic regulation of aging and outline the advances in intervention strategies for aging and age-associated diseases.A better understanding of the critical roles of epigenetics in the aging process will lead to more clinical advances in the prevention of human aging and therapy of aging-related diseases.

关 键 词：AGING PREVENTION hence 

分 类 号：R339.38[医药卫生—人体生理学]