Hide and seek with SARS-CoV-2: spike receptor-binding domain-specific memory B cells still recognize Omicron variant  

作　　者：Ivan Odak Reinhold Förster Berislav Bošnjak 

机构地区：[1]Institute of Immunology,Hannover Medical School,30625,Hannover,Germany [2]Cluster of Excellence RESIST(EXC 2155),Hannover Medical School,30625,Hannover,Germany [3]German Centre for Infection Research(DZIF),Partner site Hannover,Hannover,Germany

出　　处：《Signal Transduction and Targeted Therapy》2022年第11期3973-3975,共3页信号转导与靶向治疗（英文）

基　　金：Research in the Förster lab gets supported by the German Center for Infection Research TTU 01.938(grant no 80018019238);German Center for Lung Research(grant 82DZL002B1);Deutsche Forschungsgemeinschaft(DFG,German Research Foundation)Excellence Strategy EXC 2155“RESIST”(Project ID39087428);SFB 900/3(Project B1,158989968)and FO334/7-1(all to RF).

摘　　要：Sokal et al.reported recently in Immunity that the SARS-CoV-2 Omicron variant evades recognition by 70%of anti-spike protein antibodies generated by memory B cells(MBCs)from mRNA vaccine-immunized individuals that were either or not also infected with SARS-CoV-2.Nevertheless,samples from all analyzed persons contained MBCs with neutralizing antibodies against Omicron Spike receptor-binding domain(RBD),which provide protection against this SARS-CoV-2 variant to some degree.

关 键 词：vaccine ANTIBODIES 

分 类 号：R511[医药卫生—内科学]