Th17/Treg balance and factors related to autoimmune hepatitis  

作　　者：Miao Xue Junshuai Feng Aimin Yang Liping Gao Xuebin Peng Ni Jiang Xiaorong Mao 

机构地区：[1]Department of Rheumatology and Immunology,The First Hospital of Lanzhou University,Lanzhou,China [2]Department of Infectious Diseases,Gansu Provincial Hospital,Lanzhou,China [3]Department of Medicine&Therapeutics,The Chinese University of Hong Kong,Hong Kong,China [4]Department of Infectious Diseases,The First Hospital of Lanzhou University,Lanzhou,China

出　　处：《Rheumatology & Autoimmunity》2022年第4期221-229,共9页风湿病与自身免疫（英文）

基　　金：This study was supported by the Natural Science Fund Project of Gansu(No.1606RJZA127).

摘　　要：Background:Although Th17 cells and regulatory T cells play critical roles in autoimmune hepatitis,the balance between them in acute and chronic immune hepatitis is not well‐studied.The objective of this study was to explore the role of Th17/Treg balance in autoimmune hepatitis.Methods:Thirty female Wistar rats were randomly divided into the following three groups:acute model(AC),chronic model(CC),and healthy control(HC).Aspartate aminotransferase,alanine aminotransferase,and bilirubin levels were measured.Peripheral blood interleukin(IL)‐17,IL‐6,IL‐10,and transforming growth factor‐βcytokine levels were also assessed.Flow cytometry was used to detect changes in the Th17 cell and Treg cell frequency,and the Th17/Treg ratio was calculated.Results:The frequency of Th17 cells and Treg cells were both increased(p<0.05)and the Th17/Treg ratio was higher in the AC group compared with those in the HC group(p<0.05).Th17 cell levels were significantly lower and Treg cell levels were significantly higher in the CC group,compared with those in the AC group(p<0.05).In addition,the Th17/Treg ratio was lower in the CC group compared with that in the HC group(p<0.05).Conclusion:The Th17/Treg ratio was increased in the acute immune liver injury model and decreased in the chronic liver injury model.Th17/Treg imbalance may play a critical role in liver injury occurrence and development.

关 键 词：α‐galcer autoimmune hepatitis CONA Th17 cells Treg cells 

分 类 号：R575.1[医药卫生—消化系统] R593.2[医药卫生—内科学]