Wearable battery-free theranostic dental patch for wireless intraoral sensing and drug delivery  

作　　者：Zhenghan Shi Yanli Lu Shuying Shen Yi Xu Chang Shu Yue Wu Jingjiang Lv Xin Li Zupeng Yan Zijian An Chaobo Dai Lingkai Su Fenni Zhang Qingjun Liu 

机构地区：[1]Biosensor National Special Laboratory,Key Laboratory for Biomedical Engineering of Education Ministry,Department of Biomedical Engineering,Zhejiang University,Hangzhou 310027,P.R.China [2]Stomatology Hospital,School of Medicine,Zhejiang University,Hangzhou 310016,P.R.China

出　　处：《npj Flexible Electronics》2022年第1期518-528,共11页npj-柔性电子（英文）

基　　金：supported by the National Natural Science Foundation of China (Grant No.81971703,81801793);the National Key Research and Development Program (Grant No.2018YFC1707701)。

摘　　要：Dental caries caused by oral microbiome dysbiosis with the elevation of acidogenic bacteria is the most prevalent noncommunicable disease worldwide.Early prevention and timely fluoride treatment are crucial for caries lesion management.Herein,to address the challenges of in situ sensing and topical drug delivery within the oral cavity,a miniaturized,battery-free,and wearable dental patch system was developed for microenvironment monitoring and controlled fluoride treatment.With the integration of near-field communication,the dental patch realizes wireless energy harvesting and data transmission with mobile terminals like smartphones when attached conformally to the tooth surface.The acidic microenvironment caused by bacterial metabolism are electrochemically detected,while fluorides can be delivered locally from the electric-responsive drug delivery electrode for on-demand treatment.As flexible electronics armed to the teeth,this intraoral theranostic wearable system provides an inspiring platform for point-of-care monitoring and treatment of dental caries and oral diseases.

关 键 词：METABOLISM prevention PATCH 

分 类 号：R78[医药卫生—口腔医学] TP212[医药卫生—临床医学]