卵子成熟障碍、受精失败与早期胚胎发育阻滞遗传学研究进展  

Advances in genetics of oocyte maturation arrest, fertilization failure and early embryo arrest

作　　者：刘丽婷 高阳 贺小进[1] Liu Liting;Gao Yang;He Xiaojin(Reproductive Medicine Center of Obstetrics and Gynecology,the First Affiliated Hospital of Anhui Medical University,Anhui Province Key Laboratory of Reproductive Health and Genetics,NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract(Anhui Medical University),Hefei 230032,China)

机构地区：[1]安徽医科大学第一附属医院妇产科生殖医学中心,生殖健康与遗传安徽省重点实验室,国家卫生健康委配子及生殖道异常研究重点实验室,合肥230032

出　　处：《中华生殖与避孕杂志》2022年第12期1297-1304,共8页Chinese Journal of Reproduction and Contraception

基　　金：安徽省教育厅科研基金(gxbjZD2020061);国家重点基础研究发展计划(2019YFC1005106)。

摘　　要：卵子成熟障碍、受精失败与早期胚胎发育阻滞是生殖医学的研究热点。卵子发生和胚胎发育是非常复杂的过程。卵子成熟障碍、受精失败与胚胎发育阻滞是由包括遗传学因素在内的多种因素所导致。首例人卵母细胞成熟障碍被报道已有30年历史,直到近年来,卵母细胞成熟障碍的致病基因和分子机制在人类和小鼠模型中被广泛研究,进一步对于受精失败或胚胎发育阻滞的研究也取得了重要进展。本文结合近期最新的关于卵子成熟障碍、受精失败与胚胎发育阻滞的遗传学研究进行简要综述。Oocyte maturation arrest,fertilization failure and early embryonic arrest are the focus of modern reproductive medicine.Oogenesis is a very complex process.Oocyte maturation arrest and early embryonic arrest are caused by many genetic factors.It has been 30 years since the first case of human oocyte maturation arrest was reported.Until recent years,the pathogenic genes and molecular mechanisms of oocyte maturation arrest have been extensively studied in human and mouse models.Significant progress has been made in the study of fertilization failure or embryo development arrest.This article reviews the recent genetic studies of oocyte maturation arrest,fertilization failure and early embryonic arrest.

关 键 词：卵母细胞 不育 女性 遗传学 卵母细胞发育停滞 胚胎发育 

分 类 号：R714.8[医药卫生—妇产科学]