中药有效成分抗大肠癌转移实验研究进展  

Experimental Research Progress of Effective Components of Chinese Herbs Against Colorectal Cancer Metastasis

作　　者：蒋思沅 刘杰 JIANG Siyuan;LIU Jie

机构地区：[1]浙江中医药大学附属嘉兴中医院,浙江嘉兴314001

出　　处：《新中医》2022年第23期154-158,共5页New Chinese Medicine

基　　金：浙江省基础公益研究计划项目(LGD19C040001);嘉兴市科技计划项目(2020AD30020,2020AD10008);嘉兴市研究型医院学会科研基金项目(2021JYHA007)。

摘　　要：大肠癌是最常见的消化道恶性肿瘤之一,易发生肝、肺、骨等远处转移。中药因其多靶点、多途径且副作用较小等优势,已成为转移性大肠癌综合治疗的重要手段之一。近年来,越来越多的研究证实了中药有效成分在抑制大肠癌转移中具有一定的治疗作用,其机制与肿瘤干细胞生长、上皮-间充质转化、肿瘤血管生成、肿瘤细胞保护性自噬、失巢凋亡、肿瘤相关巨噬细胞、肠道菌群等方面调节有关。笔者综述了中药有效成分抑制大肠癌转移的研究进展,为中医药治疗大肠癌转移提供了新思路。Colorectal cancer is one of the most common malignant tumors of digestive tract,prone to distant metastasis of liver,lung and bone.Chinese medicine has become one of the important methods for the comprehensive treatment of metastatic colorectal cancer due to its advantages of multiple targets,multiple approaches and less side effects.Its mechanism is related to the regulation of tumor stem cell growth,epithelial-mesenchymal transition,tumor angiogenesis,protective autophagy of tumor cells,nest apoptosis,tumor-associated macrophages and intestinal microbiota.The authors reviews the research progress of the effective components of Chinese herbs in inhibiting colorectal cancer metastasis,which provides a new idea for the treatment of colorectal cancer metastasis by Chinese medicine.

关 键 词：大肠癌转移 中药 有效成分 肿瘤干细胞 上皮-间充质转化 自噬 凋亡 

分 类 号：R735[医药卫生—肿瘤]