结直肠癌合并原发性肝癌双原发癌的临床特征分析:附40例报告  

Characteristics of dual primary carcinoma involving colorectal and hepatic carcinoma:A retrospective analysis of 40 cases

作　　者：陈治平[1,2] 卓宪华 俞建东[1,2] 林泽宇 李国林 万云乐[1,2] Chen Zhiping;Zhuo Xianhua;Yu Jiandong;Lin Zeyu;Li Guolin;Wan Yunle(Department of Hepatobiliary Surgery,the Sixth Affiliated Hospital,Sun Yat-sen University,Guangzhou 510650,China;Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases,the Sixth Affiliated Hospital,Sun Yat-sen University,Guangzhou 510650,China;Department of Gastrointestinal Endoscopy,the Sixth Affiliated Hospital,Sun Yat-sen University,Guangzhou 510650,China)

机构地区：[1]中山大学附属第六医院肝胆胰脾外科,广州5106501 [2]中山大学附属第六医院广东省结直肠盆底疾病研究重点实验室,广州5106501 [3]中山大学附属第六医院消化内镜科,广州5106501

出　　处：《中华普通外科学文献（电子版）》2023年第1期50-54,共5页Chinese Archives of General Surgery(Electronic Edition)

摘　　要：目的研究结直肠癌(CRC)合并原发性肝癌(PHC)双原发癌患者的临床病理特征,并分析影响患者预后的危险因素。方法回顾性分析2012年7月至2021年6月中山大学附属第六医院40例CRC合并PHC双原发癌患者的临床病理资料,并结合随访资料进行生存分析。结果40例中有23例(57.5%)同时性双原发癌和17例(42.5%)异时性双原发癌患者,两组发病年龄和临床病理特征比较,差异无统计学意义。随访14(2~81)个月,31例生存,患者2年生存率为77.6%,5年生存率为61.0%。第一原发癌为CRC的患者(27例)和第一原发癌为PHC的患者(13例)生存时间比较,差异无统计学意义(P=0.346)。第一原发癌种类、发病年龄、发病间隔以及是否存在CRC相关基因突变对患者预后的影响差异无统计学意义。结论对于CRC合并PHC双原发癌患者,第一原发癌种类、发病年龄、发病间隔以及是否存在CRC相关基因突变不是影响患者预后的独立危险因素。Objective To investigate the clinicopathologic characteristics,treatment modalities,prognosis and risk factors in patients with dual primary carcinoma involving colorectal carcinoma(CRC)combined with primary hepatic carcinoma(PHC).Methods The clinicopathologic and follow-up data of 40 cases with dual primary CRC and PHC in the Sixth Affiliated Hospital,Sun Yat-sen University from July 2012 to June 2021 were retrospectively analyzed.Results Among the 40 cases,23 cases(57.5%)were diagnosed with simultaneous dual primary cancer and 17(42.5%)with metachronous dual primary cancer.There were no significant differences in age of onset and clinicopathological characteristics between the two groups.After 14 months(ranging from 2 to 81 months)of follow-up,31 cases survived.The 2-,5-year survival rate was 77.6%,61.0%respectively.The difference in overall survival between patients with CRC as the first primary cancer(27 cases)and patients with PHC as the first primary cancer(13 cases)was not statistically significant(P=0.346).There were no significant differences in the type of the first primary cancer,age of onset,interval of onset and the presence of CRC-related gene mutation on the prognosis of patients.Conclusion For patients with dual primary CRC and PHC,the type of the first primary cancer,age of onset,interval of onset,and the presence of CRC-related gene mutation are not independent risk factors affecting the prognosis of patients.

关 键 词：结直肠肿瘤 肝肿瘤 双原发癌 

分 类 号：R735.34[医药卫生—肿瘤] R735.7[医药卫生—临床医学]