失眠患者的焦虑、抑郁情绪及其与认知功能的相关性分析  

Analysis of anxiety and depression in patients with insomnia and its correlation with cognitive function

作　　者：王智康 王飞 WANG Zhikang;WANG Fei(Xi'an Daxing Hospital,Xi'an 710016;Chang'an Hospital,Xi'an 710016,China)

机构地区：[1]西安大兴医院,陕西西安710016 [2]长安医院,陕西西安710016

出　　处：《临床医学研究与实践》2023年第5期24-27,共4页Clinical Research and Practice

摘　　要：目的研究失眠患者的焦虑、抑郁情绪及其与认知功能的相关性。方法选择2016年1月至2021年2月本院收治的738例失眠患者为研究对象,根据焦虑、抑郁评估结果将其分为观察组(有焦虑、抑郁情绪,430例)和对照组(无焦虑、抑郁情绪,308例)。比较两组的睡眠质量、认知功能评分,分析焦虑、抑郁情绪与认知功能的关系。结果738例失眠患者中,有430例(58.27%)存在焦虑、抑郁情绪,其汉密尔顿焦虑量表(HAMA)评分平均(20.65±3.27)分,汉密顿抑郁量表17项(HAMD-17)评分平均(19.80±3.14)分;有308例(41.73%)无焦虑、抑郁情绪,其中HAMA评分平均(4.25±0.75)分,HAMD-17评分平均(5.06±1.12)分。对照组的睡眠质量、入睡时间、睡眠时间、睡眠效率、睡眠障碍、催眠药物、日间功能障碍评分及总分低于观察组,差异具有统计学意义(P<0.05)。对照组的注意与集中、执行功能、记忆、语言、视结构技能、抽象思维、计算和定向力评分及总分高于观察组,差异具有统计学意义(P<0.05)。Spearman相关系数分析焦虑、抑郁情绪与认知功能相关性的结果显示,观察组的HAMA、HAMD-17评分与蒙特利尔认知评估量表(MoCA)评分呈负相关(P<0.05)。结论失眠患者中约58.27%会出现焦虑、抑郁情绪,而出现焦虑、抑郁情绪患者的失眠症状会更加严重,且焦虑、抑郁情绪会对其认知功能产生直接影响,导致认知功能降低。临床在治疗失眠时应同时改善焦虑、抑郁情绪,以减轻对认知功能的影响。Objective To study the anxiety and depression in patients with insomnia and its correlation with cognitive function.Methods A total of 738 insomnia patients admitted in our hospital from January 2016 to February 2021 were selected as the research objects.According to the evaluation results of anxiety and depression,the patients were divided into observation group(with anxiety and depression,430 cases)and control group(without anxiety and depression,308 cases).The sleep quality and cognitive function scores of the two groups were compared,and the relationship between anxiety,depression and cognitive function were analyzed.Results Among the 738 patients with insomnia,430(58.27%)had anxiety and depression,the average score of Hamilton Anxiety Scale(HAMA)was(20.65±3.27),and the average score of Hamilton Depression Scale-17(HAMD-17)was(19.80±3.14);there were 308 cases(41.73%)without anxiety and depression,the average score of HAMA was(4.25±0.75),and the average score of HAMD-17 was(5.06±1.12).The sleep quality,fall asleep time,sleep time,sleep efficiency,sleep disorder,hypnotic drugs,daytime dysfunction scores and total score of the control group were lower than those of the observation group,and the differences were statistically significant(P<0.05).The attention and concentration,executive function,memory,language,visual structure skills,abstract thinking,calculation and orientation score and total score of the control group were higher than those of the observation group,and the differences were statistically significant(P<0.05).Spearman correlation coefficient analysis results of the relationship between anxiety,depression and cognitive function showed that,the HAMA and HAMD-17 scores of the observation group were negatively correlated with the Montreal Cognitive Assessment(MoCA)score(P<0.05).Conclusion About 58.27%of insomnia patients will have anxiety and depression,the insomnia symptoms of patients with anxiety and depression will be more serious,and anxiety and depression will have a direct impact on their

关 键 词：失眠 焦虑 抑郁 认知功能 汉密尔顿焦虑量表 汉密顿抑郁量表 匹兹堡睡眠质量指数 

分 类 号：R740[医药卫生—神经病学与精神病学]