对溴苯甲醛合成过程中影响因素研究  

Study on influencing factors in the synthesis of p-bromobenzaldehyde

作　　者：王克尘 梁红梅 WANG Ke-chen;LIANG Hong-mei(Jiangsu Hansoh Pharmaceutical Co.,Ld.,Lianyungang 222000,China;Jiangsu Hengrui Pharmaceutical Co.,Ld.,Lianyungang 222000,China)

机构地区：[1]江苏豪森药业集团有限公司,江苏连云港222000 [2]江苏恒瑞医药股份有限公司,江苏连云港222000

出　　处：《化学工程师》2023年第1期84-87,共4页Chemical Engineer

基　　金：连云港科学技术局重点研发项目(LYGKJZD20035)。

摘　　要：本文以二苄醚、Br_(2)为主要原料,经加Br_(2)、HNO_(3)氧化两步反应得到对溴苯甲醛,通过单因素变量实验验证了反应温度、反应时间、原料配比以及催化剂用量对对溴苯甲醛收率的影响,提出了最佳反应控制条件:反应器内温度为50℃,反应时间为8h,原料中Br_(2)与二苄醚物质的量之比为2.2∶1,催化剂Fe最佳用量为0.5g·L^(-1),在该组合条件下对溴苯甲醛收率为77.2%。研究结论可为进一步揭示对溴苯甲醛生成机制提供理论参考。In this paper,dibenzyl ether and bromine are used as the main raw materials,and p-bromobenzaldehyde is obtained by two-step reaction of bromine addition and nitric acid oxidation.The reaction temperature,reaction time,raw material ratio and catalyst dosage are verified by single-factor variable experiment to verify the effect of p-bromobenzaldehyde.The influence of the yield of benzaldehyde,the optimal reaction control conditions are proposed(the specific conditions are listed,the temperature in the reactor is 50℃,the reaction time is 8h,and the ratio of the amount of bromine and dibenzyl ether in the raw material is 2.2∶1,The optimal dosage of Fe catalyst is 0.5g·L^(-1).),the yield of p-bromobenzaldehyde was 77.2%.The research conclusion can provide a theoretical reference for further revealing the formation mechanism of p-bromobenzaldehyde.

关 键 词：对溴苯甲醛 二苄醚 溴 影响因素 

分 类 号：R914.5[医药卫生—药物化学]