生物节律在牙体硬组织发育中的作用  

Effects of circadian rhythm on the development of dental hard tissues

作　　者：宋亚玲[1] 边专[2] Song Yaling;Bian Zhuan(Department of Geriatric Dentistry,School of Stomatology,Wuhan University,Wuhan 430079,China;Department of Endodontics,School of Stomatology,Wuhan University,Wuhan 430079,China)

机构地区：[1]武汉大学口腔医学院特诊科,武汉430079 [2]武汉大学口腔医学院牙体牙髓科,武汉430079

出　　处：《中华口腔医学杂志》2023年第1期11-16,共6页Chinese Journal of Stomatology

摘　　要：生物节律受生物钟调控, 是机体通过内源性生物钟对外界循环刺激产生反应而形成。生物节律紊乱与多种疾病的发生风险密切相关, 对口腔健康的影响也不容忽视。探究生物节律与牙体硬组织发育的关系及其分子机制, 有助于深刻理解牙体硬组织发育缺陷性疾病的病因, 为牙体硬组织发育异常相关疾病的防治提供理论依据。本文在总结当前研究进展的基础上, 重点阐述生物节律参与牙体硬组织发育和形成的过程, 节律紊乱可影响牙釉质、牙本质形成, 并分析生物节律通过生物钟基因调控牙体硬组织发育的相关机制, 以期为牙发育异常疾病防治提供指导。Circadian rhythm is regulated by circadian clock,which is formed by the body response to external cyclic stimuli through the endogenous circadian clock.Circadian rhythm disturbance is closely related to the risks of a variety of diseases,and its impact on oral health cannot be ignored.Exploring the relationship and related molecular mechanism between circadian rhythm and dental hard tissues development are helpful to deeply understand the pathogenesis of developmental defects on these tissues,which could provide a theoretical basis for prevention and treatment on disorders of dental hard tissues.In order to provide guidance for the disease prevention and treatment,based on the summarization of current research progress,this paper focuses on the involvement of biorhythm in the development of tooth hard tissues as well as the disturbance of circadian rhythm on the formation of enamel and dentin,and analyzes the related regulating mechanism of circadian rhythm and genes during the development of tooth hard tissues.

关 键 词：生物钟 生物节律 生物钟基因 牙釉质发育 牙本质发育 

分 类 号：R781[医药卫生—口腔医学]