白蛋白结合型紫杉醇联合卡铂治疗晚期非小细胞肺癌的临床疗效观察  

Clinical effects of albumin-bound paclitaxel combined with carboplatin in the treatment of advanced non-small cell lung cancer

作　　者：承婷[1] 孙清[1] CHENG Ting;SUN Qing(Department of Oncology,the Second People's Hospital of Wuxi,Wuxi,214000,Jiangsu,China)

机构地区：[1]无锡市第二人民医院肿瘤内科,江苏无锡214000

出　　处：《肿瘤药学》2022年第6期775-778,共4页Anti-Tumor Pharmacy

基　　金：江苏省自然科学基金青年基金(BK20170202)。

摘　　要：目的探讨白蛋白结合型紫杉醇联合卡铂治疗晚期非小细胞肺癌的临床疗效。方法选择2018年1月至2020年1月我院收治的晚期非小细胞肺癌患者102例,按随机数字表法分为两组,各51例。对照组给予紫杉醇联合卡铂治疗,观察组给予白蛋白结合型紫杉醇联合卡铂治疗。对比两组患者的近期疗效和毒副反应发生率。结果观察组近期疗效优于对照组,差异有统计学意义(P<0.05)。两组鳞癌治疗缓解率比较,差异无统计学意义(P>0.05)。两组1~4级毒副反应发生率比较,差异均无统计学意义(P>0.05);两组3~4级毒副反应发生率比较,差异均无统计学意义(P>0.05)。结论对晚期非小细胞肺癌患者实施白蛋白结合型紫杉醇联合卡铂治疗的临床疗效明显,且毒副反应较轻,患者可耐受,值得临床推广。Objective To explore the clinical effects of albumin-bound paclitaxel combined with carboplatin in the treatment of advanced non-small cell lung cancer.Methods A total of 102 patients with advanced non-small cell lung cancer treated in our hospital between January 2018 and January 2020 were selected and divided into two groups according to the random number table method,with 51 cases in each group.Patients in control group were given paclitaxel combined with carboplatin,and those in observation group were given albumin-bound paclitaxel combined with carboplatin.The short-term efficacy and the incidence of adverse reactions were compared between the two groups.Results The short-term effect of the observation group was better than that of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the response rate of squamous cell carcinoma between the two groups(P>0.05).In addition,there was no significant difference in the incidence of grade 1~4 adverse reactions between the two groups,nor difference in the incidence of grade 3~4 adverse reactions(P>0.05).Conclusion Albumin-bound paclitaxel combined with carboplatin had good clinical effects in the treatment of patients with advanced non-small cell lung cancer.Its toxic and side effects were light and tolerable,and it was worth promoting.

关 键 词：白蛋白结合型紫杉醇 紫杉醇 晚期 非小细胞肺癌 疗效 毒副反应 

分 类 号：R734.2[医药卫生—肿瘤]