Role of smooth muscle progenitor cells in vascular mechanical injury and repair  

作　　者：Zhu-feng Dong Yan Long Wen-jie Sun Yang Wang Yu-hua Huang Gui-xue Wang Bin He Tie-ying Yin 

机构地区：[1]Key Laboratory for Biorheological Science and Technology of Ministry of Education,State and Local Joint Engineering Laboratory for Vascular Implants,Bioengineering College of Chongqing University,Chongqing,400030,China [2]Clinical Laboratory Department,Chongqing Jiulongpo District People's Hospital,Chongqing,400050,China [3]Oncology Department,Beibei Hospital of Traditional Chinese Medicine,Chongqing,400700,China

出　　处：《Medicine in Novel Technology and Devices》2022年第4期250-257,共8页医学中新技术与新装备（英文）

基　　金：the National Natural Science Foundation of China(12032007,12272071);Chongqing Research Program of Basic research and Frontier Technology(cstc2019jcyj-zdxmX0009,cstc2019jcyj-zdxmX0028).

摘　　要：Smooth muscle progenitor cells are precursor cells that express both smooth muscle cell and stem cell markers,and can differentiate into smooth muscle cells under specific condition.Smooth muscle progenitor cells exist in many tissues,including bone marrow,blood vessels,peripheral blood,skeletal muscle,and kidney.Smooth muscle progenitor cells play an important role in the pathogenesis of vascular diseases,like atherosclerosis,vascular mechanical injury and repair,and vascular restenosis.Cytokines and growth factors are released upon injury,which promote smooth muscle progenitor cells to proliferate and differentiate into smooth muscle cells at injured sites.Massive growth of smooth muscle cells stabilizes atherosclerotic plaques and accelerates neointima formation,which leads to vascular restenosis.Some drugs are now used to inhibit the differentiation and proliferation of smooth muscle cells to prevent neointima formation.In this review,we have summarized some recent progress on the smooth muscle progenitor cells’origins,tissue distributions,and their role in vascular mechanical injury and repair.

关 键 词：Smooth muscle progenitor cells RESTENOSIS Percutaneous coronary intervention ATHEROSCLEROSIS 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]