Advances on genetic and genomic studies of ALV resistance  

作　　者：Guodong Mo Ping Wei Bowen Hu Qinghua Nie Xiquan Zhang 

机构地区：[1]Guangdong Provincial Key Laboratory of Agro‑Animal Genomics and Molecular Breeding,College of Animal Science,South China Agricultural University,Guangzhou 510642,Guangdong,China [2]Key Lab of Chicken Genetics,Breeding and Reproduction,Ministry of Agriculture,Guangzhou 510642,Guangdong,China [3]State Key Laboratory for Conservation and Utilization of Subtropical Agro‑Bioresources,South China Agricultural University,Guangzhou 510642,Guangdong,China [4]Institute for Poultry Science and Health,Guangxi University,Nanning 530001,Guangxi,China.

出　　处：《Journal of Animal Science and Biotechnology》2023年第1期1-14,共14页畜牧与生物技术杂志（英文版）

基　　金：the National Natural Science Foundation of China(Grant Nos.31970540&31801030);the China Agriculture Research System of MOF and MARA(Grant No.CARS-41);the National Key R&D Program of China(Grant No.2021YFD1300100)。

摘　　要：Avian leukosis(AL)is a general term for a variety of neoplastic diseases in avian caused by avian leukosis virus(ALV).No vaccine or drug is currently available for the disease.Therefore,the disease can result in severe economic losses in poultry flocks.Increasing the resistance of poultry to ALV may be one effective strategy.In this review,we provide an overview of the roles of genes associated with ALV infection in the poultry genome,including endogenous retroviruses,virus receptors,interferon-stimulated genes,and other immune-related genes.Furthermore,some methods and techniques that can improve ALV resistance in poultry are discussed.The objectives are willing to provide some valuable references for disease resistance breeding in poultry.

关 键 词：Avian leukosis Endogenous retrovirus Gene editing IMMUNITY Interferon-stimulated genes Receptor Resistant breeding 

分 类 号：S823.2[农业科学—畜牧学]