基于核酸适配体的甲胎蛋白生物传感器研究进展  

Advances in aptamer based alpha fetoprotein biosensors

作　　者：张立娟 何宏伟 胡雪梅[1] 谢静[1] 青芳竹 ZHANG Lijuan;HE Hongwei;HU Xuemei;XIE Jing;QING Fangzhu(School of Pharmacy,Chengdu Medical College,Chengdu 610500,China;School of Electronic Science and Engineering,University of Electronic Science and Technology of China,Chengdu 610054,China)

机构地区：[1]成都医学院药学院,成都610500 [2]电子科技大学电子科学与工程学院,成都610054

出　　处：《分析试验室》2022年第11期1335-1343,共9页Chinese Journal of Analysis Laboratory

基　　金：国家自然科学基金青年基金(51802036);四川省省级大学生创新创业(S202013705123)项目资助。

摘　　要：甲胎蛋白(AFP)与肝癌及多种肿瘤的发生发展密切相关,临床上已作为原发性肝癌的血清标志物,用于原发性肝癌的诊断及疗效检测。近年来,随着分子生物技术的进步,基于AFP核酸适配体的生物传感器不断涌现,取得了一些检测方法的新突破。本文综述了基于核酸适配体的AFP生物传感器分析方法的开发与应用情况,为开发新的高灵敏度、高选择性和高特异性AFP分析方法提供参考。Alpha-fetoprotein(AFP)is closely related to the occurrence and development of liver cancer and various tumors,and has been recognized as a serum marker of primary liver cancer in clinical diagnosis and the rapeutic effect detection.In recent years,with the progress of molecular biotechnology,biosensors based on AFP aptamer have been emerging,and some meaningful break throughs in detection methods have been made.In this paper,the development and application of AFP biosensor analysis methods based on aptamers were reviewed,which could provide a reference for developing new AFP analysis methods with high sensitivity,selectivity and specificity.

关 键 词：甲胎蛋白 核酸适配体 生物传感器 

分 类 号：R914.1[医药卫生—药物化学] R917[医药卫生—药学]