脑源性神经营养因子诱发癫痫机制的研究进展  

Research progress on the mechanism of epilepsy induced by brain-derived neurotrophic factor

作　　者：肖秋杰(综述) 黄灵(审校)[2] XIAO Qiu-jie;HUANG Ling(Youjiang Medical University for Nationalities,Baise 533000,Guangxi,CHINA;Department of Neurology,Affiliated Hospital of Youjiang Medical University for Nationalities,Baise 533000,Guangxi,CHINA)

机构地区：[1]右江民族医学院,广西百色533000 [2]右江民族医学院附属医院神经内科,广西百色533000

出　　处：《海南医学》2023年第3期435-439,共5页Hainan Medical Journal

基　　金：广西高校中青年教师基础能力提升项目(编号:2018KY0439)。

摘　　要：癫痫是常见的神经系统疾病之一,目前关于其发病机制尚未完全明确。近年来,大量的研究表明脑源性神经营养因子(BDNF)在癫痫的发生和发展过程中发挥了重要作用。BDNF通过激活酪氨酸蛋白激酶B(TrkB)及p75神经营养因子受体(p75NTR)从而促进神经元细胞死亡、改变神经元兴奋性/抑制性平衡(E/I balance)、调节MicroRNA的表达、诱导海马体内苔藓纤维的异常发芽和突触重构等来进一步诱导癫痫发生。本文通过综述有关对癫痫动物模型及癫痫患者的研究文献,从而揭示BDNF参与介导癫痫的可能机制,为癫痫治疗新靶点提供参考依据。Epilepsy is one of the common neurological diseases.At present,its pathogenesis is not completely clear.Recent studies have shown that brain-derived neurotrophic factor(BDNF)plays an important role in the occurrence and development of epilepsy.BDNF can further induce epilepsy by promoting neuronal cell death[activating tyrosine protein kinase B(TrkB)and P75 neurotrophic factor receptor(p75NTR)],changing neuronal excitability/inhibitory balance(E/I balance),regulating the expression of microRNA,inducing abnormal sprouting of mossy fibers in hippocampus and synaptic remodeling.By summarizing the research literature on animal models of epilepsy and patients with epilepsy,this paper reveals the possible mechanism of BDNF in mediating epilepsy and provides a reference basis for new targets for epilepsy treatment.

关 键 词：脑源性神经营养因子 癫痫 机制 研究进展 

分 类 号：R742.1[医药卫生—神经病学与精神病学]