胸腔循环热灌注化疗对非小细胞肺癌合并胸腔积液患者的治疗效果  

Effect of intrapleural perfusion hyperthermic chemotherapy on patients with non small cell lung cancer complicated with pleural effusion

作　　者：曹栋 张娟 程艳伟 CAO Dong;ZHANG Juan;CHENG Yanwei(Department of Emergency,He’nan Provincial Key Medicine Laboratory of Nursing,He’nan Provincial People’s Hospital,Zhengzhou University People’s Hospital,He’nan University People’s Hospital,Zhengzhou 450003,He’nan,China)

机构地区：[1]河南省人民医院急诊医学科,河南省护理医学重点实验室,郑州大学人民医院,河南大学人民医院,郑州450003

出　　处：《癌症进展》2023年第1期49-52,56,共5页Oncology Progress

基　　金：河南省医学科技攻关计划项目(LHGJ20220028)。

摘　　要：目的探讨胸腔循环热灌注化疗对非小细胞肺癌合并胸腔积液患者的治疗效果。方法根据治疗方式的不同将96例非小细胞肺癌合并胸腔积液患者分为对照组(n=48)和观察组(n=48),对照组患者采取胸腔灌注化疗,观察组患者采取胸腔循环热灌注化疗。比较两组患者的临床疗效、引流管留置时间、胸腔积液总蛋白和血清C反应蛋白(CRP)水平、生活质量[欧洲癌症研究与治疗组织生命质量测定量表(EORTCQLQ-C30)]及不良反应发生情况。结果观察组患者的总有效率为95.83%,明显高于对照组患者的70.83%(P﹤0.01);观察组患者引流管留置时间明显短于对照组(P﹤0.01)。治疗后,两组患者的胸腔积液总蛋白和血清CRP水平均低于本组治疗前,且观察组患者的胸腔积液总蛋白和血清CRP水平均低于对照组,差异均有统计学意义(P﹤0.05)。治疗后,两组患者躯体功能、情绪功能、社会功能、认知功能、角色功能评分均高于本组治疗前,观察组患者躯体功能、情绪功能、社会功能、认知功能、角色功能评分均高于对照组,差异均有统计学意义(P﹤0.05)。观察组患者的不良反应总发生率明显低于对照组(P﹤0.01)。结论胸腔循环热灌注化疗治疗非小细胞肺癌合并胸腔积液患者能够提高临床疗效,缩短引流管留置时间,降低胸腔积液总蛋白和血清CRP水平,减少不良反应,改善患者生活质量。Objective To investigate the effect of intrapleural perfusion hyperthermic chemotherapy on patients with non-small cell lung cancer complicated with pleural effusion.Method A total of 96 patients with non-small cell lung cancer complicated with pleural effusion were divided into control group(n=48)and observation group(n=48)according to different treatment methods.The patients in the control group were treated with pleural perfusion chemotherapy,and the patients in the observation group were treated with intrapleural perfusion hyperthermic chemotherapy.The clinical efficacy,drainage tube indwelling time,pleural effusion total protein and serum C-reactive protein(CRP)levels,quality of life[European Organization for Research and Treatment of Cancer quality of life questionnaire core 30(EORTC QLQ C30)],and adverse reactions were compared between the two groups.Result The total effective rate of the observation group was 95.83%,which was significantly higher than 70.83%of the control group(P<0.01).The indwelling time of the drainage tube in the observation group was significantly shorter than that in the control group(P<0.01).After treatment,the pleural effusion total protein and serum CRP levels of the two groups were lower than those before treatment,and the pleural effusion total protein and serum CRP levels of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).After treatment,the physical function,emotional function,social function,cognitive function,and role function scores of the two groups were higher than those before treatment,and the above scores of the observation group were higher than those of the control group,and the differences were statistically significant(P<0.05).The total incidence of adverse events in the observation group was significantly lower than that in the control group(P<0.01).Conclusion Intrapleural perfusion hyperthermic chemotherapy for patients with non-small cell lung cancer complicated with pleural effusion cou

关 键 词：非小细胞肺癌 胸腔积液 胸腔灌注化疗 胸腔循环热灌注化疗 临床疗效 

分 类 号：R734.2[医药卫生—肿瘤]