术中射频消融后结直肠癌肝转移患者的生存情况及影响因素分析  

Survival of patients with liver metastasis of colorectal cancer and the influencing factors after intraoperative radiofrequency ablation

作　　者：张相成[1] 何亚丽[1] 胡义超 ZHANG Xiangcheng;HE Yali;HU Yichao(Department of General Surgery,Pingdingshan First People’s Hospital,Pingdingshan 467000,He’nan,China)

机构地区：[1]平顶山市第一人民医院普外科,河南平顶山467000

出　　处：《癌症进展》2023年第1期78-81,共4页Oncology Progress

摘　　要：目的探讨术中射频消融后结直肠癌肝转移患者的生存情况及影响因素。方法选取142例接受术中射频消融治疗的结直肠癌肝转移患者,所有患者均随访3年,记录其总生存期,采用Cox比例风险回归模型分析术中射频消融后结直肠癌肝转移患者生存情况的影响因素。结果142例患者中未出现失访病例,随访3年,死亡107例,生存35例,3年生存率为24.65%。不同年龄、转移灶直径、转移灶数目、癌胚抗原(CEA)水平、化疗时机、合并症情况结直肠癌肝转移患者的3年生存率比较,差异均有统计学意义(P﹤0.05)。Cox多因素回归分析结果显示,年龄≥60岁、转移灶数目﹥3、CEA水平≥5 ng/ml、化疗时机为术前、有合并症均是术中射频消融后结直肠癌肝转移患者生存情况的危险因素(P﹤0.05)。结论术中射频消融后结直肠癌肝转移患者生存情况的影响因素较多,包括年龄、转移灶数目、CEA水平、化疗时机及合并症等,临床上应格外重视各种因素,及时诊断和治疗,进一步提高患者生存率。Objective To analyze the survival of patients with liver metastasis of colorectal cancer and the influencing factors after intraoperative radiofrequency ablation.Method A total of 142 patients with liver metastasis of colorectal cancer who received intraoperative radiofrequency ablation were selected and followed up for 3 years to record the overall survival.The factors that may affect the survival of colorectal cancer patients with liver metastasis after intraoperative radiofrequency ablation were analyzed.Result No loss of 3-year follow-up was found in 142 patients,of which 107 patients died and 35 survived,with 3-year survival rate of 24.65%.There were significant differences in 3-year survival rate of colorectal cancer patients with liver metastasis in different ages,diameter and number of metastatic foci,carcinoembryonic antigen(CEA)levels,timing of chemotherapy and complications(P<0.05).The Cox multivariate regression analysis showed that age≥60,metastatic foci>3,CEA level≥5 ng/ml,preoperative chemotherapy and complications were risk factors for survival of colorectal cancer patients with liver metastasis after intraoperative radiofrequency ablation(P<0.05).Conclusion There are various influencing factors for survival in colorectal cancer patients with liver metastasis after intraoperative radiofrequency ablation,including age,metastatic foci,CEA level,timing of chemotherapy and complications,which should be emphasized in clinic with timely diagnosis and treatment to improve survival rate of patients.

关 键 词：结直肠癌 肝转移 射频消融 生存情况 

分 类 号：R735.3[医药卫生—肿瘤]