盐酸安罗替尼对晚期肝癌患者肝功能、基质金属蛋白酶、血管内皮生长因子受体2及预后的影响  

Effect of anlotinib hydrochloride on liver function,matrix metalloproteinase,vascular endothelial growth factor receptor 2 and prognosis in patients with advanced liver cancer

作　　者：李晨 查岭[1] 赵贝 徐继业[2] LI Chen;ZHA Ling;ZHAO Bei;XU Jiye(Department of Pharmacy,Zhoukou Central Hospital,Zhoukou 466000,He’nan,China;Department of Medical Oncology,Zhoukou Central Hospital,Zhoukou 466000,He’nan,China)

机构地区：[1]周口市中心医院药学部,河南周口466000 [2]周口市中心医院肿瘤内科,河南周口466000

出　　处：《癌症进展》2023年第1期101-104,共4页Oncology Progress

摘　　要：目的探讨盐酸安罗替尼对晚期肝癌患者肝功能、基质金属蛋白酶(MMP)、血管内皮生长因子受体2(VEGFR2)及预后的影响。方法根据治疗方法的不同将102例晚期肝癌患者分为观察组和对照组,每组51例,对照组患者予以经导管动脉栓塞化疗(TACE),观察组患者在对照组的基础上予以盐酸安罗替尼治疗。比较两组患者的肝功能指标[白蛋白(ALB)、丙氨酸转氨酶(ALT)、总胆红素(TBIL)]、MMP2、MMP9、MMP11、VEGFR2水平、不良反应发生情况及预后。结果治疗后,两组患者的ALB水平均高于本组治疗前,ALT、TBIL水平均低于本组治疗前,观察组患者的ALB水平高于对照组,ALT、TBIL水平均低于对照组,差异均有统计学意义(P﹤0.05)。治疗后,两组患者的血清MMP2、MMP9、MMP11、VEGFR2水平均低于本组治疗前,观察组患者的血清MMP2、MMP9、MMP11、VEGFR2水平均低于对照组,差异均有统计学意义(P﹤0.05)。两组患者发热、腹痛、乏力、瘙痒、腹泻、恶心呕吐发生率比较,差异均无统计学意义(P﹥0.05)。观察组患者3个月、6个月、1年生存率均高于对照组,差异均有统计学意义(P﹤0.05)。结论晚期肝癌患者在TACE的基础上采用盐酸安罗替尼治疗可有效改善肝功能,调节MMP和VEGFR2水平,安全性较高,临床应用效果显著。Objective To explore the effect of anlotinib hydrochloride on liver function,matrix metalloproteinase(MMP),vascular endothelial growth factor receptor 2(VEGFR2)and prognosis in patients with advanced liver cancer.Method A total of 102 patients with advanced liver cancer were divided into control group[n=51,received transcatheter arterial chemoembolization(TACE)]and observation group(n=51,received TACE+anlotinib hydrochloride)according to different treatment methods.The liver function indexes[albumin(ALB),alanine aminotransferase(ALT),and total bilirubin(TBIL)],levels of MMP2,MMP9,MMP11,VEGFR2,adverse reactions and prognosis were compared between the two groups.Result After treatment,the levels of ALB in both groups were higher than those before treatment,and the levels of ALT and TBIL were lower than those before treatment,with higher level of ALB and lower levels of ALT and TBIL in the observation group than those in the control group(P<0.05).After treatment,the serum levels of MMP2,MMP9,MMP11 and VEGFR2 in both groups were lower than those before treatment,with lower levels in the observation group than those in the control group(P<0.05).There were no significant differences for the incidence of fever,abdominal pain,fatigue,itching,diarrhea,nausea and vomiting between the two groups(P>0.05).The 3-month,6-month,1-year survival rate in the observation group were significantly higher than those in the control group(P<0.05).Conclusion Anlotinib hydrochloride combined TACE in the treatment of patients with advanced liver cancer can effectively improve liver function,adjust MMP and VEGFR2 levels,with higher safety and significant clinical effect.

关 键 词：盐酸安罗替尼 肝癌 肝功能 基质金属蛋白酶 血管内皮细胞生长因子受体2 预后 

分 类 号：R735.7[医药卫生—肿瘤]