金纳米簇放射治疗增敏作用的研究进展  

Research progress in gold nanoclusters for radiosensitization

作　　者：邓芳 刘思思 贺睿敏 谭华欣 Deng Fang;Liu Sisi;He Ruimin;Tan Huaxin(Department of Pathology,First Affiliated Hospital of University of South China,Hengyang 421000,China;Department of Biochemistry and Molecular Biology,School of Basic Medicine,Hengyang Medical School,University of South China,Hengyang 421000,China;Department of Radiotherapy,Second Affiliated Hospital of University of South China,Hengyang 421000,China)

机构地区：[1]南华大学附属第一医院病理科,衡阳421000 [2]南华大学衡阳医学院基础医学院生物化学与分子生物学教研室,衡阳421000 [3]南华大学附属第二医院放疗科,衡阳421000

出　　处：《中华放射医学与防护杂志》2022年第12期1010-1014,共5页Chinese Journal of Radiological Medicine and Protection

基　　金：国家自然科学基金(31800846)。

摘　　要：目前恶性肿瘤的放射治疗疗效仍欠满意, 放疗增敏剂是提高放疗疗效的有效手段。金纳米材料因其高原子序数可有效增加肿瘤细胞的放疗敏感性。金纳米簇因其更小的尺寸有更加优良的放射生物学、放射物理学特性。本文综述了金纳米簇特殊的放射生物学、放射物理学特性, 并详细地介绍了其对外照射放疗、放射性核素治疗、X射线诱导的光动力治疗的增敏作用。Radiotherapy still fails to achieve satisfactory efficacy in the treatment of malignant tumors,and applying radiotherapy sensitizers is an effective method to improve the efficacy of radiotherapy.Gold nanomaterials can effectively increase the sensitivity of tumor cells to radiotherapy due to their high atomic numbers.Gold nanoclusters have more excellent radiobiological and radiophysical properties due to their smaller size.This paper reviews the special radiobiological and radiophysical properties of gold nanoclusters and describes in detail their sensitizing effects in external radiation radiotherapy,radionuclide therapy,and X-ray induced photodynamic therapy.

关 键 词：放射治疗 放疗增敏剂 金纳米簇 

分 类 号：R730.55[医药卫生—肿瘤]