Construction of a 980 nm laser-activated Pt(Ⅱ)metallacycle nanosystem for efficient and safe photo-induced bacteria sterilization  

作　　者：Yuling Xu Chonglu Li Jusung An Xin Ma Jingfang Yang Lishi Luo Yun Deng Jong Seung Kim Yao Sun 

机构地区：[1]Key Laboratory of Pesticides and Chemical Biology,Ministry of Education,International Joint Research Center for Intelligent Biosensor Technology and Health,College of Chemistry,Central China Normal University,Wuhan 430079,China [2]Department of Chemistry,KoreaUniversity,Seoul 02841,Republic of Korea [3]Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules,Hubei University,Wuhan 430062,China [4]State Key Laboratory of Chemo/Biosensing and Chemometrics,Hunan University,Changsha 410082,China [5]Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education,Jianghan University,Wuhan 430056,China

出　　处：《Science China Chemistry》2023年第1期155-163,共9页中国科学（化学英文版）

基　　金：supported by National Natural Science Foundation of China(22022404,22074050,21904103);the Fundamental Research Funds for the Central Universities(CCNU22QN007);the Open Research Fund of State Key Laboratory of Chemo/Biosensing and Chemometrics(2021005);the Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules Hubei University(KLSAOFM2111);the Opening Project of Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education,Jianghan University(JDGD-202209);the Open Project Program of Key Laboratory for Analytical Science of Food Safety and Biology,Ministry of Education(FS2202);supported by the CRI project of National Research Foundation of Republic of Korea(2018R1A3B1052702,JSK)。

摘　　要：Although metal-based chemical agents have demonstrated promising bacteriostatic effects in phototherapy,their short excitation/emission wavelengths and inadequate phototherapy efficiencies make their application in vivo difficult.We therefore synthesized a novel Pt(Ⅱ)metallacycle(Pt1110)that can be activated with a 980 nm laser for photodiagnosis/treatment in deep tissue.We found that Pt1110 significantly improved photothermal conversion(95%improvement)and ^(1)O_(2) generation(ΦΔ75%increase)compared to the ligand itself 1 and was well capable of light-induced sterilization under safe laser irradiation(0.72 W/cm^(2)).In addition,Pt1110 has little to no toxicity to cells.After incorporated into liposome,Pt1110 NPs was effective in wound healing in infection and keratitis models upon laser irradiation,which was accurately observed by NIR-Ⅱfluorescence imaging.This novel metal-coordinated supramolecular material has a potential to become a universal platform for phototherapy in deep tissue.

关 键 词：supramolecular chemistry METALLACYCLE NIR-Ⅱfluorescence imaging phototheranostics deep penetration 

分 类 号：TN248[电子电信—物理电子学]