小细胞肺癌长期生存患者的临床病理特征及预后影响因素  

Clinicopathologic characteristics and prognostic factors of long-term survival patients with small cell lung cancer

作　　者：马丽娜 李宁宁 陈新宇 Ma Lina;Li Ningning;Chen Xinyu(Department of Medical Record Management,Zhumadian Central Hospital,Zhumadian 463000,China;Department of Respiratory Medicine,Zhumadian Central Hospital,Zhumadian 463000,China;Department of Internal Medicine-Oncology,Zhumadian Central Hospital,Zhumadian 463000,China)

机构地区：[1]驻马店市中心医院病案管理科,驻马店463000 [2]驻马店市中心医院呼吸内科,驻马店463000 [3]驻马店市中心医院肿瘤内科,驻马店463000

出　　处：《中国实用医刊》2022年第19期37-40,共4页Chinese Journal of Practical Medicine

摘　　要：目的分析小细胞肺癌长期生存患者的临床病理特征及预后影响因素。方法抽取2016年1月至2022年5月驻马店市中心医院收治的小细胞肺癌患者150例,回顾性分析其临床资料。按照患者生存时间分为长期生存组(生存时间>24个月,32例)和短期生存组(生存时间≤24个月,118例)。比较两组患者的临床病理特征及免疫组化指标,分析影响小细胞肺癌长期生存患者预后的因素。结果长期生存组乳酸脱氢酶水平低于短期生存组,发生肝转移占比(6.25%,2/32)低于短期生存组(23.73%,28/118),P<0.05;肝转移、细胞增殖抗原(Ki67)表达、甲状腺转录因子-1(TTF-1)是影响小细胞肺癌患者长期生存的单因素(P<0.05);Logistic回归分析结果显示,无肝转移、Ki67≤77%、TTF-1呈阳性表达是小细胞肺癌患者长期生存的保护因素(P<0.05)。结论小细胞肺癌长期生存患者与短期生存患者在临床病理特征方面存在明显差异性,且肝转移、Ki67、TTF-1是影响小细胞肺癌患者长期生存和预后的重要因素。Objective To analyze the clinicopathologic characteristics and prognostic factors of long-term survival patients with small cell lung cancer(SCLC).Methods A total of 150 patients with SCLC admitted to Zhumadian Central Hospital from January 2016 to May 2022 were selected,and their clinical data were analyzed retrospectively.According to the survival time,the patients were divided into long-term survival group(survival time>24 months,32 cases)and short-term survival group(survival time≤24 months,118 cases).The clinicopathological characteristics and immunohistochemical indexes of the two groups were compared,and the factors affecting the prognosis of patients with long-term survival of SCLC were analyzed.Results The lactate dehydrogenase level in the long-term survival group was lower than that in the short-term survival group,and the proportion of liver metastasis(6.25%,2/32)was lower than that in the short-term survival group(23.73%,28/118),P<0.05.Liver metastasis,nuclear-associatedantigen Ki-67(Ki67)expression and thyroid transcription factor-1(TTF-1)were the single factors affecting the long-term survival of SCLC patients(P<0.05).Results of Logistic regression analysis showed that no liver metastasis,Ki67≤77%and TTF-1 positive expression were protective factors for long-term survival of SCLC patients(P<0.05).Conclusions There are significant differences in clinicopathological characteristics between long-term and short-term survival patients with SCLC,moreover,liver metastasis,Ki67 and TTF-1 are important factors affecting the long-term survival and prognosis of SCLC patients.

关 键 词：小细胞肺癌 长期生存 临床病理特征 预后 

分 类 号：R734.2[医药卫生—肿瘤]