CD56^(neg)NK细胞在HIV感染的作用:进展与展望  

The characterization of CD56^(neg) NK cell in HIV infections:progress and Outlook

作　　者：于明航 黎紫怡 王玺 赵红心 YU Minghang;LI Ziyi;WANG Xi;ZHAO Hongxin(Beijing Key Laboratory of Emerging Infectious Diseases,Institute of Infectious Diseases,National Center for Infectious Diseases,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China;Clinical Center for HIVlAIDS,Clinical and Research Center of Infectious Diseases,Beijing Ditan Hospital,Capital Medical University,Beijing100015)

机构地区：[1]首都医科大学附属北京地坛医院传染病研究所北京市感染性疾病研究中心国家医学传染病研究中心北京市新发传染病重点实验室,北京100015 [2]首都医科大学附属北京地坛医院艾滋病临床中心,北京100015

出　　处：《中国艾滋病性病》2022年第12期1453-1456,共4页Chinese Journal of Aids & STD

基　　金：北京市医管中心项目(DFL20191802);北京市医院管理局临床医学发展专项(ZYLX202126)。

摘　　要：HIV是导致人体免疫功能严重缺陷的RNA病毒,而自然杀伤(NK)细胞作为固有免疫系统中的天然免疫细胞,可以通过不同的杀伤机制抑制HIV的感染和复制。在急性期,NK细胞可以通过抗体依赖的细胞介导的细胞毒性作用(Antibody Dependent Cell Mediated Cytotoxicity,ADCC)对HIV感染的细胞进行有效的杀伤和清除。随着HIV感染的进展,NK细胞逐渐表现出功能耗竭,以及出现功能异常的CD56^(neg)NK细胞亚群,最终导致NK细胞功能受损。尽管NK细胞对于抗HIV感染的作用已多有研究,但对于CD56^(neg)NK细胞亚群的功能研究甚少。CD56^(neg)NK细胞亚群在健康人中比较少见,主要常见于HIV感染者中,但对其功能及来源仍不清楚。本文主要通过阐述CD56^(neg)NK细胞亚群在HIV感染中的作用,对其可能起源进行总结概括,以明确NK细胞在抗HIV感染过程中发挥的重要作用。HIV is an RNA virus that causes serious defects in human immune function.Natural killer(NK)cells are innate immunity that play a critical role in the control of HIV infections and replication.In the acute phase,NK cells can effectively lysis and clear HIV infected cells through antibody-dependent cell-mediated cytotoxicity(ADCC).Chronic stages of HIV infections have anegative impact on NK cell function and promote the appearance of phenotypically and dysfunctional CD56^(neg)NK cell subset.In particular,it has been observed the function of NK cells,however,the function of CD56^(neg)NK cells subsets in anti-HIV infection has been poorly studied.The CD56^(neg)NK cell is relatively rare in healthy people and its function and origin are unclear.We mainly summarize the functional role of CD56^(neg)NK cell subsets in HIV and its possible origin in this review to definite the important role of NK cell subsets in anti-HIV infection.

关 键 词：艾滋病病毒 CD56^(neg)NK细胞 NK细胞 ADCC 抗病毒 

分 类 号：R512.91[医药卫生—内科学] R373.9[医药卫生—临床医学]