云南高校图书馆联盟文献共享服务平台- ADCC

ADCC: 作品数：107被引量：272H指数：8; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：于传飞王兰刘春雨黄瑾王文波更多>>; 相关机构：中国食品药品检定研究院华中科技大学南京中医药大学中国疾病预防控制中心更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家科技重大专项教育部“新世纪优秀人才支持计划”江苏省教委自然科学基金更多>>

单抗药物Fc效应功能机制及检测方法研究进展: 《山东化工》2025年第3期119-124,共6页张坤成孔霄玥方雅覃一枫陈悦秦国宏; 单克隆抗体作为一种具有靶向性的药物在肿瘤治疗方面具有良好的效果,因此抗体药物的研发一直是国内外学者关注的焦点。目前上市的抗体药物绝大多数为IgG亚型,因其高度的特异性,Fab端能够识别并结合抗原,而Fc端通常能介导机体免疫系统发...; 关键词：单克隆抗体 IGG ADCC CDC

ADCC增强型Claudin18.2单克隆抗体的制备和体内外活性: 《中国医药工业杂志》2025年第2期190-197,共8页朱中松彭伟刘忠张贵民赵丽丽; 泰山产业领军人才工程项目(tscx202306088)。; Claudin18.2抗体在胃癌治疗中具有巨大的潜力。然而,受限于其非人源序列和较弱的受体亲和力,已上市抗体的疗效和安全性仍有待改善。该研究通过杂交瘤筛选、抗体人源化和抗体依赖性细胞毒性(ADCC)作用的改造,获得了特异性结合Claudin18....; 关键词：胃癌 Claudin18.2单克隆抗体杂交瘤技术抗体人源化抗体依赖性细胞毒性基因工程

Xianling Lianxia formula improves the efficacy of trastuzumab by enhancing NK cell-mediated ADCC in HER2-positive BC: 《Journal of Pharmaceutical Analysis》2024年第10期1450-1467,共18页Feifei Li Youyang Shi Mei Ma Xiaojuan Yang Xiaosong Chen Ying Xie Sheng Liu; This work was supported by the National Natural Science Foundation of China(Grant No.:81774308);the Multi-center Clinical Research Project for Major Diseases of Shanghai Shenkang Hospital Development Center,China(Grant No.:SHDC2020CR1050B);the High-level University Building Innovation Team,China(Grant No.:601521D).; Trastuzumab has improved survival rates in human epidermal growth factor receptor 2(HER2)-positive breast cancer(BC),but drug resistance leads to treatment failure.Natural killer(NK)cell-mediated antibody-dependent ce...; 关键词：HER2-positive breast cancer Traditional chinese medicine TRASTUZUMAB NK cell ADCC effect

免疫组化MYB和Notch1在乳腺腺样囊性癌中的应用: 《临床与实验病理学杂志》2024年第9期942-947,共6页张晓红张晓丽韦志永王晓映眭怡群刘晓江王志蕙姚少波薛梅; 临沂市科技发展计划项目(2022YX0077)。; 目的探讨MYB、Notch1免疫组化染色在经典型乳腺腺样囊性癌(classic adenoid cystic carcinoma of the breast, C-AdCC)、具有基底细胞样特征的实体型乳腺腺样囊性癌(solid-basaloid adenoid cystic carcinoma of the breast, SB-AdCC)...; 关键词：乳腺肿瘤 C-AdCC SB-AdCC MYB NOTCH1

A novel method to assess antibody-dependent cell-mediated cytotoxicity against influenza A virus M2 in immunized murine models: 《Biosafety and Health》2024年第3期178-185,共8页Yinjie Liang Junjia Guo Zhen Li Shiyuan Liu Ting Zhang Shucai Sun Funa Lu Yuqian Zhai Wenling Wang Chuanyi Ning Wenjie Tan; the National Key Research and Development Program of China(2021YFC2300101).; The matrix protein 2 (M2) is a preferred target for developing a universal vaccine against the influenza A virus (IAV). This study aimed to develop a method for assessing antibody-dependent cell-mediated cytotoxicity ...; 关键词：Antibody-dependent cell-mediated cytotoxicity(ADCC) Influenza A virus(IAV) Matrix protein 2 extracellular domain(M2e) Cell line

Role of Fc-mediated Ab functions in HIV and SARS-Cov-2 vaccine prevention: 《感染控制(英文)》2024年第1期26-31,共6页Li-Yun Lin Aiwei Zhu Bin Su Christiane Moog; funded by the National Key R&D Program of China(2023YFE0116000);the High-Level Public Health Specialized Talents Project of Beijing Municipal Health Commission(2022-2-018);Beijing Key Laboratory for HIV/AIDS Research(BZ0089);ANRS(Agence Nationale de Recherches sur le SIDA et les hépatites virales),the Investissements d’Avenir program managed by the ANR under reference ANR-10-LABX-77 and EHVA(N°681032,Horizon 2020);supported by the Strasbourg’s Interdisciplinary Thematic Institute(ITI)for Precision Medicine,TRANSPLANTEX NG,as part of the ITI 2021-2028 program of the University of Strasbourg,CNRS and INSERM;funded by IdEx Unistra[ANR-10-IDEX-0002]and SFRI-STRAT’US[ANR-20-SFRI-0012];the European regional development fund(European Union)INTERREG V program(project Personalis);MSD-Avenir grant AUTOGEN,for their financial supports.; The purpose of vaccination is to generate Neutralizing antibodies(NAbs),as these antibodies have neutralizing activity against viral infections such as HIV and SARS-CoV-2.NAb has high antiviral potency and therefore b...; 关键词：neutralizing antibody non-neutralizing antibody FC ADCC HIV SARS-CoV-2

Bispecific antibody targeting both B7-H3 and PD-L1 exhibits superior antitumor activities: 《Acta Pharmacologica Sinica》2023年第11期2322-2330,共9页Hua-ying Li Yi-li Chen Xiang-nan Deng Huan-huan Li Jie Tan Guo-jian Liu Yu-juan Zheng Min Pei Kai-ting Peng Li-li Yue Xiao-jia Chen Yu Liu Yong-shan Zhao Chun-he Wang; supported by the National Natural Science Foundation of China(81872785);Shanghai Municipal Commission of Science and Technology of China(21S11904500);Major Scientific and Technological Special Project of Zhongshan City(191022172638719 and 210205143867019);CAS Bohai Rim Advanced Research Institute for Drug Discovery Project(LX211005);the Research&Development Plan in Key Areas of Guangdong Province(2022B1111070007).; Clinical application of PD-1 and PD-L1 monoclonal antibodies (mAbs) is hindered by their relatively low response rates and the occurrence of drug resistance. Co-expression of B7-H3 with PD-L1 has been found in various...; 关键词：cancer immunotherapy B7-H3 PD-L1 bispecific antibodies VHH antibody-dependent cell-mediated cytotoxicity(ADCC)

SARS-CoV-2特异性抗体ADCC活性与抗体滴度和中和活性呈正相关: 《中华微生物学和免疫学杂志》2023年第9期718-726,共9页钟可馨温莺芬张绪磊邢晓敏庾蕾; 市校(院)联合资助项目(202201020528)。; 目的:探讨SARS-CoV-2感染者血浆样本抗体依赖细胞介导的细胞毒作用(antibody-dependent cell-mediated cytotoxicity,ADCC)及其与抗体滴度和中和活性的相关性。方法:采用表达SARS-CoV-2刺突(spike;S)蛋白的HEK293T细胞为靶细胞,表达Fcγ...; 关键词：SARS-CoV-2 抗体依赖细胞介导的细胞毒作用(ADCC) 中和活性假病毒血浆抗体

CD56^(neg)NK细胞在HIV感染的作用:进展与展望: 《中国艾滋病性病》2022年第12期1453-1456,共4页于明航黎紫怡王玺赵红心; 北京市医管中心项目(DFL20191802);北京市医院管理局临床医学发展专项(ZYLX202126)。; HIV是导致人体免疫功能严重缺陷的RNA病毒,而自然杀伤(NK)细胞作为固有免疫系统中的天然免疫细胞,可以通过不同的杀伤机制抑制HIV的感染和复制。在急性期,NK细胞可以通过抗体依赖的细胞介导的细胞毒性作用(Antibody Dependent Cell Medi...; 关键词：艾滋病病毒 CD56^(neg)NK细胞 NK细胞 ADCC 抗病毒

HER2胞外段及相关蛋白增强赫赛汀ADCC功能的研究被引量：1: 《国际免疫学杂志》2022年第2期130-137,共8页胡林晗郑航孙莹张敏郑源强石艳春陈国江; 国家自然科学基金(81672803,81871252,81660272)。; 目的探讨人表皮生长因子受体-2(human epidermal growth factor receptor 2,HER2)蛋白的哪种结构域更适合激发赫赛汀抗体依赖的细胞介导的细胞毒性(antibody-dependent cell-mediated cytotoxicity,ADCC)效应。方法真核表达五种包含HER...; 关键词：人表皮生长因子受体-2 赫塞汀自然杀伤细胞抗体依赖的细胞介导的细胞毒性

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