Role of Fc-mediated Ab functions in HIV and SARS-Cov-2 vaccine prevention  

作　　者：Li-Yun Lin Aiwei Zhu Bin Su Christiane Moog 

机构地区：[1]Laboratoire d’Immuno-Rhumathologie Moléculaire,Institut national de la santéet de la recherche médicale(INSERM)UMR_S 1109,Institut thématique interdisciplinaire(ITI)de Médecine de Précision de Strasbourg,Transplantex NG,Facultéde Médecine,Fédération Hospitalo-Universitaire OMICARE,Fédération de Médecine Translationnelle de Strasbourg(FMTS),Universitéde Strasbourg,Strasbourg,France [2]Beijing Key Laboratory for HIV/AIDS Research,Clinical and Research Center for Infectious Diseases,Beijing Youan Hospital,Capital Medical University,Beijing,China [3]Sino-French Joint Laboratory for HIV/AIDS Research,Sino-French Joint Laboratory for Research on Humoral Immune Response to HIV Infection,Beijing Youan Hospital,Capital Medical University,Beijing,China [4]Vaccine Research Institute(VRI),Créteil,France

出　　处：《感染控制(英文)》2024年第1期26-31,共6页

基　　金：funded by the National Key R&D Program of China(2023YFE0116000);the High-Level Public Health Specialized Talents Project of Beijing Municipal Health Commission(2022-2-018);Beijing Key Laboratory for HIV/AIDS Research(BZ0089);ANRS(Agence Nationale de Recherches sur le SIDA et les hépatites virales),the Investissements d’Avenir program managed by the ANR under reference ANR-10-LABX-77 and EHVA(N°681032,Horizon 2020);supported by the Strasbourg’s Interdisciplinary Thematic Institute(ITI)for Precision Medicine,TRANSPLANTEX NG,as part of the ITI 2021-2028 program of the University of Strasbourg,CNRS and INSERM;funded by IdEx Unistra[ANR-10-IDEX-0002]and SFRI-STRAT’US[ANR-20-SFRI-0012];the European regional development fund(European Union)INTERREG V program(project Personalis);MSD-Avenir grant AUTOGEN,for their financial supports.

摘　　要：The purpose of vaccination is to generate Neutralizing antibodies(NAbs),as these antibodies have neutralizing activity against viral infections such as HIV and SARS-CoV-2.NAb has high antiviral potency and therefore be served as therapeutics.However,induction of NAb is not easy,and RNA viruses such as HIV and SARS-CoV-2 always escape NAb binding epitopes due to the rapid mutation of their genomes.Thus,despite Fab and neutralizing,other component and its function against viral infection is important in the biology of antibodies,such as the Fc part in antibodies.Fc-mediated function showed protective potency in viral infection.Fc-mediated ADCC contributes to protect against HIV in phase II/III clinical trial,but remains controversy.Marginal evidences show protectivity of non-NAb and Fc-mediated ADCC in HIV infection and AIDS progress.In SARS-CoV-2 infection,Fc-mediated ADCC showed potent antiviral activity as well.While,the participation of non-NAb is elusive in the control of HIV and SARS-CoV-2 dual infection.Limited data reported that Fc-mediated functions is regulated following HIV infection as people living with HIV after vaccination of pulmonary pathogens display increased ADCC activity to homologues pathogens.In order to reveal Fc-mediated function,there is a need to actively develop a robust and accurate in vitro assay to measure it.This is an emerging attract that have drawn much attention.

关 键 词：neutralizing antibody non-neutralizing antibody FC ADCC HIV SARS-CoV-2 

分 类 号：R51[医药卫生—内科学]