血清AFP、HE4、CA125对卵巢癌早期诊断及病理分期判定的价值  被引量:7

The Value of Serum AFP,HE4 and CA125 in Early Diagnosis and Pathological Staging of Ovarian Cancer

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作  者:王怀明 WANG Huaiming(First People's Hospital of Wuxue City,Hubei Province,Wuxue 435400,China)

机构地区:[1]湖北省武穴市第一人民医院,湖北武穴435400

出  处:《中国医学创新》2023年第2期96-100,共5页Medical Innovation of China

摘  要:目的:探究血清甲胎蛋白(AFP)、人附睾蛋白4(HE4)及糖类抗原125(CA125)对卵巢癌早期诊断及病理分期判定的价值。方法:收集2019年8月-2021年12月武穴市第一人民医院收治的卵巢癌(80例,卵巢癌组)及卵巢良性肿瘤患者(80例,良性肿瘤组),并纳入同期体检健康女性(80例,对照组),检测三组研究对象血清AFP、HE4、CA125水平,对比卵巢癌组内不同病理分期及病理类型患者间AFP、HE4、CA125水平差异,并以病理结果为金标准计算单一指标及联合检测的诊断效能。结果:卵巢癌组血清AFP、HE4、CA125水平均显著高于良性肿瘤组、对照组(P<0.05),良性肿瘤组均显著高于对照组(P<0.05);Ⅰ、Ⅱ期卵巢癌血清AFP、HE4、CA125水平均显著低于Ⅲ、Ⅳ期患者(P<0.05);浆液性癌患者血清AFP、HE4、CA125水平均显著高于黏液性癌患者及内膜样癌患者(P<0.05),黏液性癌患者均显著高于内膜样癌患者(P<0.05);联合检测诊断敏感度、特异度、准确率最高,分别为95.00%、88.75%、91.88%。结论:卵巢癌患者与卵巢良性肿瘤患者及健康女性血清AFP、HE4、CA125有显著差异,此三项血清指标可用于卵巢癌早期诊断、病理分期及病理类型判定,联合检测时诊断效果达到最佳。Objective: To explore the value of serum alpha-fetoprotein(AFP), human epididymal protein 4(HE4) and carbohydrate antigen 125(CA125) in the early diagnosis and pathological staging of ovarian cancer.Method: From August 2019 to December 2021, patients with ovarian cancer(80 cases, ovarian cancer group)and ovarian benign tumors(80 cases, benign tumor group) admitted to First People’s Hospital of Wuxue City were collected, and healthy women(80 cases, control group) who underwent physical examination during the same period were included. The serum AFP, HE4 and CA125 levels of the research subjects were compared, and the differences in AFP, HE4 and CA125 levels among patients with different pathological stages and pathological types in the ovarian cancer group were compared, and the pathological results were used as the gold standard to calculate the diagnostic efficacy of single index and combined detection. Result: The levels of serum AFP, HE4 and CA125 in ovarian cancer group were significantly higher than those in benign tumor group and control group(P<0.05), and those in benign tumor group were significantly higher than those in control group(P<0.05). The levels of AFP,HE4 and CA125 in patients with stage Ⅰ and Ⅱ were significantly lower than those in patients with stage Ⅲ and Ⅳ(P<0.05);the levels of serum AFP, HE4 and CA125 in patients with serous carcinoma were significantly higher than those in patients with mucinous carcinoma and endometrioid carcinoma(P<0.05). Patients with mucinous carcinoma were significantly higher than those with endomyoid carcinoma(P<0.05);the combined detection had the highest diagnostic sensitivity, specificity, and accuracy, which were 95.00%, 88.75% and 91.88%, respectively.Conclusion: There are significant differences in serum AFP, HE4 and CA125 between ovarian cancer patients and ovarian benign tumor patients and healthy women. These three serum indicators can be used for early diagnosis,pathological staging and pathological type determination of ovarian cancer, and the

关 键 词:卵巢癌 血清甲胎蛋白 人附睾蛋白4 糖类抗原125 病理分期 病理类型 

分 类 号:R737.31[医药卫生—肿瘤]

 

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