COMPARISON OF AMINOLEVULINIC ACID AND ITS METHYL ESTER MEDIATED PHOTOCYTOTOXICITY ON HUMAN NASOPHARYNGEAL CARCINOMA CELLS  

作　　者：CHRISTINE M.N.YOW RICKY W.K.WU ZHENG HUANG 

机构地区：[1]Medical Laboratory Science Department of Health Technology Informatics Hong Kong Polytechnic University,Hong Kong SAR,China [2]Department of Radiation Oncology University of Colorado Denver,CO,USA [3]MOE Key Laboratory of OptoElectronic Science and Technology for Medicine Fujian Normal University,Fuzhou,China

出　　处：《Journal of Innovative Optical Health Sciences》2012年第2期25-33,共9页创新光学健康科学杂志（英文）

基　　金：This project was partially supported by a Hong Kong Polytechnic University grant(GU737).

摘　　要：Nasopharyngeal carcinoma(NPC)is a prevalent cancer in some areas of southern Asia.To explore the potential of photodynamic therapy(PDT)for the treatment of NPC,a small molecule prodrug 5-aminolevulinic acid(ALA)and its methyl ester(MAL)mediated PDT was studied in vitro.The results showed that human NPC cells were sensitive to both ALA-and MAL-mediated PDT.However,ALA was more effective than MAL,possiblly due to a higher efficiency of ALA on producing endogenous protoporphyrin(PpIX)in NPC cells.Neither ALA nor MAL caused any significant genotoxicity.The ALA-based PDT might be a useful modality in the treatment ofNPC.

关 键 词：Aminolevulinic acid methylaminolevulinate nasopharyngeal carcinoma photodynamic therapy 

分 类 号：R73[医药卫生—肿瘤]