Treatment of cutaneous lichen planus with ALA-mediated topical photodynamic therapy  

作　　者：Zhi-Xia Fan Ling-Lin Zhang Hong-Wei Wang Pei-Ru Wang Zheng Huang Xiu-Li Wang 

机构地区：[1]Shanghai Skin Diseases Hospital Shanghai 200050,P.R.China [2]Shanghai Skin Diseases Clinical College of Anhui Medical University Shanghai 200050,P.R.China [3]Department of Dermatology Huadong Hospital,Shanghai 200040,P.R.China [4]University of Colorado Denver Cancer Center and CAPT Lab,CO,USA

出　　处：《Journal of Innovative Optical Health Sciences》2015年第1期88-94,共7页创新光学健康科学杂志（英文）

基　　金：supported by grants from the National Natural Science Foundation of China (81272990);the Natural Science Foundation of Shanghai (11ZR1432800);the Key Project of Shanghai Health Bureau (A 20124034).

摘　　要：Purpose:To evaluate the efectiveness of topical 5-aminolevulinie acid(ALA)-mediated pho-todynamic therapy(PDT)for the treatment of cutaneous lichen planus(LP).Methods:A total of 17 symptomatic LP lesions in 7 Chinese patients were assessed.ALA cream(10%)was applied topically to LP lesions for 3h.The lesions were iradiated with a 635 nm diode laser at the dose level of 100J/cm^(2).The treatment was repeated at two week intervals.Clinical assessmnent was conducted before each treatment.Follow-up was performed once a month for up to six months.Results:Lesions showed significant improvement after one to four courses of treatments.Complete response was achieved in 13 lesions(five patients)and partial remission in four lesions(two patients).The complete response rate was 71%.There was no significant side ffects except the feeling of pain that most patients could tolerate.Follow-up of five patients who achieved complete response showed no signs of recurrence.Conclusion:Topical ALA PDT is effective in the treatment of cutaneous LP.

关 键 词：5-aninolevulinic acid photodynamie therapy lichen planus 

分 类 号：R73[医药卫生—肿瘤]