THE EXPERIMENTAL STUDY OF STRESS-RELATED PATHOLOGICAL CHANGES IN CEREBRAL VENOUS BLOOD FLOW IN NEWBORN RATS ASSESSED BY DOCT  

作　　者：OXANA V.SEMYACHKINA-GLUSHKOVSKAYA VLADISLAV V.LYCHAGOV OLGA A.BIBIKOVA IGOR A.SEMYACHKIN-GLUSHKOVSKIY SERGEY S.SINDEEV EKATERINAM.ZINCHENKO MOHHANAD M.KASSIM AL-FATLE FATEMA ALI AL HASSANI LEITH MARIA V.ULANOVA VALERY V.TUCHIN 

机构地区：[1]Department of Biology,Saratov State University,Astrachanskaya Str.83410012 Saratov,Russian Federation [2]Department of Biology,Al-Mustansiriya University,Baghdad,Iraq [3]Institute of Precise Mechanics and Control of Russia Academy of Science Rabochaya 28,410028 Saratov,Russian Federation [4]Optoelectronics and Measurement Techniques Laboratory University of Oulu,P.O.BOX 450090014 University of Oulu,Finland

出　　处：《Journal of Innovative Optical Health Sciences》2013年第3期76-85,共10页创新光学健康科学杂志（英文）

基　　金：This work was supported in part by RF Govern-mental contracts 11.519.11.2035,14.B37.21.0728,14.B37.21.0563;14.B37.21.0216 and grants:FiDiPro,TEKES Program(40111/11),Finland;SCOPES EC,Uzb/Switz/RF,Swiss NSF,IZ74ZO_137423/1;RF President's grant"Scientific Schools",1177.2012.2.,Russian Foundation for Basic Research Grant No.12-02-31204 mol-a and No.a-11-02-00560.

摘　　要：In experiments on newbom rats with stress related intracrani al hemorhage(ICH)using Doppler optical coberence tomognaphy(DOCT)we have shown that latent stage of ICH(4 h after stress)is characterized by decrease of venous blood outflow and the loss of sensitivity of sagittal vein to vasoconstrictor ffect of adrenaline.The incidence of ICH(24 h after stress)was accompanied by progressi on of early pathological changes in cerebral venous blood flow(CVBF)and development of venous insufficiency.Taking into consideration of this fact,we suggest that the suppression of CVBF related to the severity to the deleterious effect of stress on the brain hemodynamics in newborn rats.These facts allow us to conclude that the venous insufficiency with the loss of vasoconstrictor response to adrenaline is an informative and sensitive component of pattern of CVBF that can be important diagnostic criteria of risk of ICH development in newborns.

关 键 词：Doppler optical coherence tomography stress related intracnanial hemorthage cerebral venous blood flow ADRENALINE 

分 类 号：R74[医药卫生—神经病学与精神病学]