Optical coherence tomography of the living human kidney  

作　　者：Peter M.Andrews Hsing-Wen Wang Jeremiah Wierwlle Wei Gong Jennifer Verbesey Matthew Cooper Yu Chen 

机构地区：[1]Department of Biochemistry,Molecular.and Celular Biology Georgetown University Medical,Center Washington,DC20007,USA [2]Fischell Department of Bioengineering,Uriversity of Maryland College Park,MD 20742,USA [3]Colege of Photonic and Electric Engineering Fujian Normal University,Fuzhou,China [4]Medstar,Georgetown Transplant Inste Georgetown University Medical Center Washington,D C 20007,USA

出　　处：《Journal of Innovative Optical Health Sciences》2014年第2期88-97,共10页创新光学健康科学杂志（英文）

摘　　要：Acute tubular necrosis(ATN)induced by ischemia is the most common insult to donor kidneysdestined for trarsplantation.ATN results from sweling and subsequent damage to cells lining thelkidney tubules.In this study,we demonstrate the capability of optical coherence tomography(OcT)to image the renal microst ructures of living human donor kidneys and potentially providea measure to det ermine the extent of A TN.We also found that Doppler-based OCT(i.e.,DOCT)reveals renal blood flow dynamics that is another major factor which could relate to post-transplant renal finction.All OCT/DoCT oberva tions were performed in a noninvasive,sterileand timely manner on intact human kidneys both prior to(er vivo)and following(in vivo)theirtransplantation.Our results indicate that this imaging model provides transplant surgeons withan objective visualization of the transplant lidneys prior and immediately post transplantation.

关 键 词：Optical coherence tomography doppler optical coherence tomography acute tubularnecrosis kidney transplantation uriniferous tubules GLOMERULUS renal blood flow 

分 类 号：R69[医药卫生—泌尿科学]