COMBINED EFFECTS OF SELECTIVE PHOTOTHERMAL THERAPY AND IMMUNOADJUVANT AGAINST STAGE IV BREAST CANCER  

作　　者：XIAOSONG LI TOMAS HODE MARIA C.GUERRA GABRIELA L.FERREL JOHN A.LUNN ORN ADALSTEINSSON ROBERT E.NORDQUIST WEI R.CHEN 

机构地区：[1]Department of Oncology the First Affiliated Hospital of Chinese PLA General Hospital Beijing 100048,China [2]Department of Laser Medicine Chinese PLA General Hospital Beijing 100853,China [3]Department of Engineering and Physics University of Central Oklahoma 100 N.University Drive,Edmond Oklahoma 73034,USA [4]ImmunoPhotonics Inc.,1601 South Providence Road Columbia,Missouri 65211,USA [5]Hospital Nacional Edgardo Rebagliati Martins Av.Edgardo Rebagliati#490—Jesus Maria,Lima,Peru [6]Collins Ave.,P.O.Box N-215 Nassau,The Bahamas [7]International Strategic Cancer Alliance 873 E.Baltimore Pike#333,Kennett Square Philadelphia 19348,USA

出　　处：《Journal of Innovative Optical Health Sciences》2010年第4期279-284,共6页创新光学健康科学杂志（英文）

基　　金：supported in part by a grant from the US National Institutes of Health(P20 RR016478 from the INBRE Program of the National Center for Research Resources).

摘　　要：Metastasis to distant sites is a severe treatment challenge and a major cause of death for breast cancer patients.Laser immunotherapy(LIT)is a novel technique,combining a selective photothermal therapy with local application of glycated chitosan,a potent immunoadjuvant.The pre-clinical studies of LIT have shown its unique characteristics in generating specific antitumor immunity.The clinical application of LIT in the treatment of melanoma patients has achieved preliminary success.Recently,LIT has been used to treat late-stage breast cancer patients.Here we report for the first time the clinical results of this combination therapy in breast cancer patients.The LIT treatment procedures are presented and the medical history of two stage Ⅳ breast cancer patients is reviewed.Most of the breast cancer lesions and the metastasis of lung and brain disappeared after repeated treatments of LIT.One patient achieved complete response;the other achieved partial response at the time of this report.Although there is still a long way for LIT to become a standard modality for breast cancer treatment,the results of this study indicated its promising future.

关 键 词：Laser immunotherapy near-infrared laser glycated chitosan indocyanine green metastasis cancer stage IV breast cancer patients clinical trials 

分 类 号：R73[医药卫生—肿瘤]