In vivo tumor detection with com bined MR-Photoacoustic-Thermoacoustic imaging  

作　　者：Lin Huang Wei Cai Yuan Zhao Dan Wu Lei Wang Yuqing Wang Dakun Lai Jian Rong Fabao Gao Huabei Jiang 

机构地区：[1]School of Physical Electronics University of Electronic Science and Technology of China Chengdu 610054,P.R.China [2]Department of Biomedical Engineering University of Florida,FL 32611,USA [3]Department of Radiology,West China Hospital Sichuan University,Chengdu,Sichuan 610041,P.R.China

出　　处：《Journal of Innovative Optical Health Sciences》2016年第5期38-47,共10页创新光学健康科学杂志（英文）

基　　金：supported by the Chinese Govern-ment's 1000-Talent Plan via the University of Elec-tronic Science and Technology of China and by the J.Crayton Pruitt Family Endowment(to HJ);the National Natural Science Foundation of China(81130027 and 81520108014);the National"Twelfth FiveYear"Plan for Science&Technology Support(2012BAI23B08);the National Basic Research Program of China(973 Program,2011CB935800)(to FG).

摘　　要：Here,we report a new method using combined magnetic resonance(MR)-Photoacoustic(PA)-Thermoacoustic(TA)imaging techmiques,and demonstrate its unique ability for in vrivo cancer detection using tumor-bearing mice.Circular scanning TA and PA imaging systems were used to recover the dielectric and optical property dist ributions of three colon carcinoma bearing mice While a 7.0-T magnetic resonance imaging(MRI)unit with a mouse body volume coil was utilized for high resolution structural imaging of the same mice.Three plastic tubes flled with soybean sauce were used as fiducial markers for the co-registration of MR,PA and TA images.The resulting fused images provided both enhanced tumor margin and contrast relative to the surrounding normal tissues.In particular,some finger-like protrusions extending into the surrounding tissues were revealed in the MR/TA infused images.These results show that the tissue functional optical and dielectric properties provided by PA and TA images along with the anatomical structure by MRI in one picture make accurate tumor identification easier.This combined MR-PA-TA-imaging strategy has the potential to offer a dinically useful triple-modality tool for accurate cancer detection and for intraoper ative surgical navigation.

关 键 词：THERMOACOUSTIC PHOTOACOUSTIC MRI in vivo tumor detection 

分 类 号：R73[医药卫生—肿瘤]