SETD7在肿瘤发生发展中的作用及机制的研究进展  

Research Progress of Role and Mechanism of SETD7 in Tumor Occurrence and Progression

作　　者：曹丽敏 王岷[1] 徐克[1] Limin CAO;Min WANG;Ke XU(Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment,Tianjin Lung Cancer Institute,Tianjin Medical University General Hospital,Tianjin 300052,China)

机构地区：[1]天津医科大学总医院,天津市肺癌研究所,天津市肺癌转移和肿瘤微环境重点实验室,天津300052

出　　处：《中国肺癌杂志》2023年第1期38-45,共8页Chinese Journal of Lung Cancer

基　　金：天津市教委科研计划项目(No.2020KJ150)资助。

摘　　要：肿瘤的发生是个复杂的过程,不仅取决于本身基因的突变或缺失,还受表观遗传调控的影响。近年来研究表明甲基化修饰在转录调控、异染色质的形成、X染色体失活、DNA损伤、肿瘤的发生发展等众多过程中均发挥着重要作用。含SET域赖氨酸甲基转移酶7(SET domain containing lysine methyltransferase 7,SETD7)是体内一种重要的赖氨酸甲基转移酶,可甲基化组蛋白,也可使非组蛋白甲基化。这种修饰调节方式一旦发生紊乱可直接导致细胞异常,从而引起多种疾病的发生。研究表明SETD7与多种肿瘤的发生发展具有相关性,但是有关SETD7甲基化底物位点及其在相应肿瘤中的调控机制并未完全阐明。本文将就SETD7对组蛋白及非组蛋白的甲基化修饰在肿瘤中发挥的作用及调控分子机制等方面的研究进展加以概述,以期为肿瘤的发病机制及诊疗研究提供新的治疗靶点。The occurence and development of tumors is a complicated process,which not only depends on the mutation or deletion of genes,but also is affected by epigenetic regulation.Accumulating evidences have shown that epigenetic modifications play fundamental roles in transcriptional regulation,heterochromatin formation,X chromosome inactivation,DNA damage response and tumor development.SET domain containing lysine methyltransferase 7(SETD7)was initially identified as an important lysine methyltransferase,which methylated histone and non-histone proteins.These modifications play fundamental roles.Once this modification disorders,it can directly lead to cell abnormalities and cause many diseases.Studies have shown that SETD7 is related to the occurence and development of various tumors,but the methylation sites of SETD7 and its regulatory mechanism have not been fully elucidated.This article summarizes the research progress of the role of SETD7 on histone and non-histone methylation modification in tumors and the molecular mechanism,in order to provide new therapeutic targets for tumor pathogenesis and diagnosis.

关 键 词：SETD7 甲基化 组蛋白及非组蛋白底物 肿瘤进展 

分 类 号：R730.2[医药卫生—肿瘤]