循环miRNA作为颅内动脉瘤生物标志物的研究进展  

Recent advance in circulating micro RNAs as biomarkers in intracranial aneurysm

作　　者：朱艺琳 刘嘉棋 田昊 孙海涛[3] Zhu Yilin;Liu Jiaqi;Tian Hao;Sun Haitao(Second Clinical Medical College,Southern Medical University,Guangzhou 510282,China;Neurosurgery Center,National Key Clinical Specialty,Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Diseases,Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration,Neurosurgery Institute of Guangdong Province,Zhujiang Hospital,Southern Medical University,Guangzhou 510282,China;Clinical Biological Sample Resource Center of Zhujiang Hospital,Southern Medical University,Guangzhou 510282,China)

机构地区：[1]南方医科大学第二临床医学院,广州510282 [2]南方医科大学珠江医院神经外科中心,国家临床重点专科,脑血管病诊断与治疗教育部工程研究中心,广东省普通高校脑功能修复与再生重点实验室,广东神经外科研究所,广州510282 [3]南方医科大学珠江医院临床生物样本资源中心,广州510282

出　　处：《中华神经医学杂志》2022年第12期1269-1275,共7页Chinese Journal of Neuromedicine

基　　金：广东省基础与应用基础研究基金(2020A1515010038);南方医科大学珠江医院院长基金(yzjj2018rc03);大学生创新创业项目(S202112121058)。

摘　　要：体液中的微小RNA(miRNA)采集方便,创伤性小,具有作为颅内动脉瘤(IA)生物标志物的潜力,适合于IA的早期筛查与破裂预测。稳定存在于血清、血浆等体液中的miRNA(即循环miRNA)参与调控血管平滑肌细胞和内皮细胞功能,在IA发生与进展的病理生理过程中发挥重要作用。本文现围绕循环miRNA作为生物标志物在IA早期诊断、破裂预测及预后评估中的研究现况综述如下。Micro RNAs in body fluids,enjoying convenient collection and less invasion,have the potential of being biomarkers of intracranial aneurysm(IA),and are suitable for early screening and rupture prediction of IA.The stable micro-RNAs(circulating micro RNAs)in serum,plasma and other body fluids are involved in regulating the functions of vascular smooth muscle cells and endothelial cells,and play important roles in pathophysiological process of IA progression.In this paper,the current research progress of circulating micro RNAs as biomarkers in the early diagnosis,rupture prediction and prognoses of IA are summarized as follows.

关 键 词：颅内动脉瘤 破裂 微小RNA 生物标志物 

分 类 号：R743[医药卫生—神经病学与精神病学]