髓过氧化物酶与脑卒中关系的研究进展  

Recent advance in relation of myeloperoxidase with stroke

作　　者：周逸华 刘学润 郭名君 关勇 张祎年 Zhou Yihua;Liu Xuerun;Guo Mingjun;Guan Yong;Zhang Yinian(First Clinical Medicine College,Lanzhou University,Lanzhou 730000,China;Department of Critical Care Medicine,Third Xiangya Hospital,Central South University,Changsha 410013,China;Department of Neurosurgical Oncology,Neurosurgery Center,National Key Clinical Specialty,Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease,Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration,Neurosurgery Institute of Guangdong Province,Zhujiang Hospital,Southern Medical University,Guangzhou 510282,China)

机构地区：[1]兰州大学第一临床医学院,兰州730000 [2]中南大学湘雅三医院重症医学科,长沙410013 [3]南方医科大学珠江医院神经外科中心,神经肿瘤外科,国家临床重点专科,脑血管病诊断与治疗教育部工程研究中心,广东省普通高校脑功能修复与再生重点实验室,广东神经外科研究所,广州510282

出　　处：《中华神经医学杂志》2022年第12期1290-1296,共7页Chinese Journal of Neuromedicine

基　　金：甘肃省基础研究创新群体项目(21JR7RA432);兰州大学君政基金(LZU-JZH2525);兰州大学第一医院卓越计划项目(20210060005)。

摘　　要：脑卒中是中枢神经系统最常见的疾病,致残率和致死率均很高,在严重影响患者生活质量的同时造成了巨大的社会负担,然而目前整体的治疗效果仍不理想。髓过氧化物酶(MPO)是中性粒细胞来源的过氧化物酶,可能通过多种途径在脑卒中的发生发展中起着重要作用,在脑卒中的早期诊断、临床治疗、预后评估等方面存在极大潜力。本研究围绕MPO与脑卒中关系的研究进展进行综述,旨在为临床中更好地诊治脑卒中提供新的思路。Stroke is the most common disease of the central nervous system,with high disability and mortality,which seriously affects the quality of life of patients and causes a huge disease burden.However,the overall treatment effect is still unsatisfied at present.Myeloperoxidase(MPO),a kind of peroxidase derived from neutrophils,may play an important role in stroke development through many ways,and has great potential in early diagnosis,clinical treatment and prognosis evaluation of stroke.This article reviews the research progress of MPO in stroke,aiming to provide new ideas for better diagnosis and treatment of stroke in clinic.

关 键 词：髓过氧化物酶 脑卒中 炎症 氧化应激 血脑屏障 脑保护 

分 类 号：R743.3[医药卫生—神经病学与精神病学]