Scientific connotation of “treating different diseases with the same method” from the perspective of metabolic-immune dysregulation in inflammation-mediated carcinogenesis of digestive organs  

作　　者：Xia Ding Yunze Liu Ruilin Wang Hong Shen Qi Wang 

机构地区：[1]Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China [2]School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 102488,China [3]Centre of Research for Traditional Chinese Medicine Digestive,Beijing University of Chinese Medicine,Beijing 100029,China [4]Department of Hepatology of Traditional Chinese Medicine,The Fifth Medical Center of PLA General Hospital,Beijing 100039,China [5]Digestive Department,Jiangsu Province Hospital of Chinese Medicine,Nanjing 210029,China [6]National Institute of TCM Constitution and Preventive Medicine,Beijing University of Chinese Medicine,Beijing 100029,China

出　　处：《Journal of Traditional Chinese Medical Sciences》2023年第1期3-9,共7页中医科学杂志（英文）

基　　金：supported by National Natural Science Foundation of China(92059102 and 81630080);the National Key Research and Development Plan of China(2018YFC1704106).

摘　　要：Inflammation-mediated carcinogenesis develops in the context of chronic inflammation and is a significant cause of cancer within the digestive system.In the chronic inflammation microenvironment,the metabolic activity of tissue cells undergoes extensive changes,which interfere with the normal function of immune cells.Dysregulation of cell metabolism and immune function has been identified as a key factor contributing to inflammation-mediated carcinogenesis within the major digestive organs,such as the stomach,liver,and colorectum.This metabolic-immune imbalance also corresponds to traditional Chinese medicine(TCM)theories of“yin-yang disharmony”and“disharmony between Ying-nutrients and Wei-defense.”The metabolic-immune imbalance has also been regarded as the key factor supporting“treatment of different diseases with the same method”,in which the same approach is adopted in the treatment of different conditions.In the TCM treatment process,it is necessary to first identify TCM patterns and then apply the corresponding TCM to correct the dysregulated metabolic and immune function,thereby blocking the progression from inflammation to malignancy.Our study findings deepen the TCM understanding of metabolic-immune dysregulation and the relationship between metabolic-immune dysregulation,pattern identification,and treatment method.They also provide new insights for the treatment of inflammation-mediated carcinogenesis in major digestive organs and help us further explore the scientific connotation of the TCM strategy of“treating different diseases with the same method”.

关 键 词：Inflammation-mediated carcinogenesis Treating different diseases with the same method Metaboliceimmune regulation Metabolism Immunity Digestive system 

分 类 号：R73[医药卫生—肿瘤]