首发未治疗精神分裂症患者QTc间期延长发生情况及影响因素研究  

The prevalence and influencing factors of QTc interval prolongation in first-episode untreated schizophrenia patients

作　　者：曹海燕 孙凌[1] 雷彤[1] 焦清艳[2] 李研哲 孙萧萧 王中刚 李洁[3] CAO Haiyan;SUN Ling;LEI Tong;JIAO Qingyan;LI Yanzhe;SUN Xiaoxiao;WANG Zhonggang;LI Jie(Institute of Mental Health,Tianjin Anding Hospital,Tianjin 300222,China)

机构地区：[1]天津市安定医院儿童青少年心理科,天津3002222 [2]天津市安定医院睡眠科 [3]天津市安定医院精神病学研究所 [4]天津医科大学研究生院 [5]山东省戴庄医院精神科

出　　处：《中国神经精神疾病杂志》2022年第12期724-729,共6页Chinese Journal of Nervous and Mental Diseases

基　　金：天津市科技计划慢性病防治科技重大专项(编号:2017ZXMFSY00070);天津市医学重点学科(专科)建设项目资助(编号:TJYXZDXK-033A)。

摘　　要：目的 研究首发未治疗精神分裂症患者心电图QTc间期延长的发生情况及影响因素。方法 2018年11月至2020年11月招募203例首发未治疗精神分裂症患者(精神分裂症组)和505名年龄、性别匹配的健康对照(对照组)。两组进行心电图检查,记录心率、QTc间期,精神分裂症患者进行血常规、肝功能、肾功能、甲状腺功能等血液学指标检测。结果 精神分裂症组心率较对照组快[(78.49±11.12)次/分vs.(74.95±8.88)次/分],QTc间期较对照组长[(424.42±23.60)ms vs.(420.06±21.66)ms],差异有统计学意义(P<0.05)。精神分裂症组QTc间期延长发生率高于对照组(5.91%vs.2.38%),差异有统计学意义(P<0.05)。男性精神分裂症患者QTc间期延长发生率高于男性对照(11.69%vs.3.66%),差异有统计学意义(P<0.05);女性组间无统计学差异(P>0.05)。精神分裂症患者QTc间期多因素线性回归分析显示,空腹血糖(β=0.163,P=0.025)与QTc间期相关。结论 首发未治疗精神分裂症患者QTc间期延长,空腹血糖升高可能与精神分裂症患者QTc间期延长相关联。Objective To study the prevalence and influencing factors of QTc interval prolongation in first-episode untreated schizophrenia. Methods Two hundred and three first-episode untreated schizophrenia patients(schizophrenia group) and 505 age and sex matched healthy controls(control group) were enrolled in the study from November 2018 to November 2020. The general data and clinical data of patients were collected, and the hematological indexes were detected. Electrocardiogram was performed in both groups, and the heart rate, QTc interval were recorded.We compared the prevalence of QTc interval prolongation between schizophrenia group and control group. Correlation analysis and regression analysis were used to analyze the possible influencing factors of QTc interval prolongation in first-episode untreated schizophrenia. Results The heart rate of schizophrenia patients was significantly faster than that of control group(P<0.05). Compared with control group, QTc interval of schizophrenia patients was significantly longer(P<0.05). The prevalence of QTc prolongation of schizophrenia patients was higher than that of control group(5.91% vs.2.38%, P<0.05). The prevalence of QTc prolongation in male patients was higher than that in male control group(11.69%vs. 3.66%, P<0.05). The multiple regression analysis showed that fasting plasma glucose(β=0.163, P=0.025) was related to QTc interval. Conclusion This study has demonstrated that QTc interval of first-episode untreated schizophrenia is longer than that of control group, and QTc interval prolongation may be one of the characteristics of schizophrenia. Fasting plasma glucose may be associated with QTc interval prolongation in schizophrenia patients.

关 键 词：首发 未治疗 精神分裂症 QTC间期 QTC间期延长 发生率 影响因素 

分 类 号：R749.3[医药卫生—神经病学与精神病学]