白细胞介素10受体A在炎症性肠病发病机制中的研究进展  

Research progress on interleukin-10 receptor A in the pathogenesis of inflammatory bowel disease

作　　者：熊毅云 许玲芬[1] Xiong Yiyun;Xu Lingfen(Department of Pediatric Gastroenterology,Shengjing Hospital of China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院小儿消化内科,沈阳110004

出　　处：《中国小儿急救医学》2022年第12期1003-1006,共4页Chinese Pediatric Emergency Medicine

基　　金：辽宁省自然科学基金资助计划(2019-MS-372);辽宁省科技厅民生科技计划联合计划(2021JH2/10300094)。

摘　　要：炎症性肠病(IBD)是一种复杂的多因素疾病,其特征是慢性复发性肠道炎症。IBD的病因尚未明确,相关研究主要集中在宿主的遗传易感性、免疫反应、肠道微生物组和环境因素等方面。研究发现白细胞介素10受体A(IL-10RA)在IBD的发病中发挥重要作用,IL-10RA不仅可以影响肠屏障和肠道免疫,而且IL-10RA自身突变与极早发型IBD高度相关。Inflammatory bowel disease(IBD)is a complex multifactorial disease characterized by chronic recurrent intestinal inflammation.The etiology of IBD has not yet been determined,and relevant studies have focused on the genetic susceptibility,immune response,intestinal microbiome and environmental factors of the host.Studies have found that interleukin-10 receptor A(IL-10RA)plays important roles in the pathogenesis of IBD.IL-10RA can not only affect the intestinal barrier,but also affect the intestinal immune system.Furthermore,the mutation of IL-10RA itself is highly correlated with very early-onset IBD.

关 键 词：炎症性肠病 白细胞介素10受体A 肠屏障 免疫 遗传 

分 类 号：R574[医药卫生—消化系统]