Hippo通路调节代谢对眼部发育及疾病的影响  

Effects of regulated metabolism by Hippo pathway on ocular development and diseases

作　　者：郭洋 朱曼辉 宋鄂[1] Guo Yang;Zhu Manhui;Song E(Lixiang Eye Hospital of Soochow University,Suzhou 215021,China)

机构地区：[1]苏州大学理想眼科医院,215021

出　　处：《国际眼科纵览》2022年第5期396-401,共6页International Review of Ophthalmology

基　　金：江苏省自然科学基金(BK20191177)。

摘　　要：Hippo通路的核心由激酶级联、转录辅助激活因子和DNA结合蛋白构成,靶向调节多种生物过程,包括细胞生长、分化、再生和器官大小的控制。Hippo通路参与三大物质代谢,包括葡萄糖代谢、脂质代谢、谷氨酰胺代谢,并通过单独或协同PI3K/Akt/mTOR、TGF-β、Wnt/β-cateninh及Notch信号通路等调节眼部的生长发育、视网膜新生血管相关性眼病、青光眼、白内障等眼部疾病的发生发展。The core of the Hippo pathway is composed of kinase cascades,transcriptional coactivators,and DNA-binding proteins that target a variety of biological processes,including the control of cell growth,differentiation,regeneration,and organ size.Recently,many studies have shown that Hippo pathway is involved in the metabolism of three substances,including glucose metabolism,lipid metabolism and glutamine metabolism.At the same time,Hippo pathway can regulate the growth and development of eyes,the incidence and development of retinal neovascularization,glaucoma,cataract and other eye diseases alone or in coordination with PI3K/Akt/mTOR,TGF-β,Wnt/β-cateninh and Notch signaling pathways.

关 键 词：Hippo通路 Yes相关蛋白 物质代谢 

分 类 号：R77[医药卫生—眼科]